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Tclin
FXYD2
Sodium/potassium-transporting ATPase subunit gamma

Protein Summary
Description
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260287
  • ENSP00000260287
  • ENSG00000137731
  • ENST00000292079
  • ENSP00000292079
  • ENST00000528014
  • ENSP00000432430
  • ENST00000532119
  • ENSP00000436414

Symbol
  • ATP1C
  • ATP1G1
  • HOMG2
  • ATP1G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
cellular component
0.63
tissue
0.62
transcription factor
0.62
cell type or tissue
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.74   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.74   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3