FXYD2
Sodium/potassium-transporting ATPase subunit gamma
Protein Summary
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
- ENST00000260287
- ENSP00000260287
- ENSG00000137731
- ENST00000292079
- ENSP00000292079
- ENST00000528014
- ENSP00000432430
- ENST00000532119
- ENSP00000436414
- ATP1C
- ATP1G1
- HOMG2
- ATP1G1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
cellular component | 0.63 | ||
tissue | 0.62 | ||
transcription factor | 0.62 | ||
cell type or tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.74 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 82 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.74 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 82 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3