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Tbio
FXYD1
Phospholemman

Protein Summary
Description
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phosphol ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351325
  • ENSP00000343314
  • ENSG00000266964
  • ENST00000455515
  • ENSP00000393611
  • ENST00000588081
  • ENSP00000467727
  • ENST00000588607
  • ENSP00000468535
  • ENST00000588715
  • ENSP00000465289
  • ENST00000589209
  • ENSP00000466398
  • ENST00000612146
  • ENSP00000481244

Symbol
  • PLM
  • PLM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
gene perturbation
0.86
molecular function
0.73
PubMedID
0.69
tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.09   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 266   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 264.09   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 266   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
NDRG1
Tbio
Novelty:  0.00352631
p_int:  0.9999995
p_ni:  5e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
NDRG3
Tbio
Novelty:  0.05968882
p_int:  0.999998347
p_ni:  4.4e-7
p_wrong:  0.000001214
Score:  0.355
Data Source:  BioPlex,STRINGDB
NDRG4
Tbio
Novelty:  0.01974969
p_int:  0.999988531
p_ni:  0.000005689
p_wrong:  0.00000578
Score:  0.266
Data Source:  BioPlex,STRINGDB
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.999979452
p_ni:  0.000020548
Score:  0.175
Data Source:  BioPlex,STRINGDB
GCHFR
Tbio
Family:  Enzyme
Novelty:  0.04287433
p_int:  0.999206635
p_ni:  0.000793365
Score:  0.157
Data Source:  BioPlex,STRINGDB
ATP6V1D
Tbio
Family:  Enzyme
Novelty:  0.02298626
p_int:  0.997324893
p_ni:  0.002675105
p_wrong:  2e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.990671961
p_ni:  0.009328039
Data Source:  BioPlex
FAM204A
Tdark
Novelty:  0.74892948
p_int:  0.870622443
p_ni:  0.108573801
p_wrong:  0.020803755
Score:  0.345
Data Source:  BioPlex,STRINGDB
PRTFDC1
Tbio
Family:  Enzyme
Novelty:  0.13607881
p_int:  0.83082914
p_ni:  0.02937574
p_wrong:  0.13979512
Score:  0.157
Data Source:  BioPlex,STRINGDB
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.828618347
p_ni:  0.17130928
p_wrong:  0.000072372
Score:  0.232
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 8
ATP1B3
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
ATP1B2
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
ATP1B1
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
ATP1A4
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
ATP1A3
Tclin
Family:  Transporter
KEGG Distance:  1
Common Pathways:  1
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
6
8
99.2
calcium measurement
1
4
4
97.1
blood protein measurement
2
4
4
96.9
sex hormone-binding globulin measurement
6
2
6
94.7
mean platelet volume
3
3
3
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
8
99.2
calcium measurement
4
97.1
blood protein measurement
4
96.9
sex hormone-binding globulin measurement
6
94.7
mean platelet volume
3
93.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 1
VGNC:11111
747770
Mouse
MGI:1889273
56188
Rat
RGD:69306
58971
Dog
FXYD domain containing ion transport regulator 1
VGNC:41019
476487
Horse
FXYD domain containing ion transport regulator 1
VGNC:18163
100630886
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 1
Mouse
Rat
Dog
FXYD domain containing ion transport regulator 1
Horse
FXYD domain containing ion transport regulator 1
Publication Statistics
PubMed Score 264.09
PubMed score by year
PubTator Score 216.76
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title