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Tbio
FUT9
Alpha-(1,3)-fucosyltransferase 9

Protein Summary
Description
Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides. The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302103
  • ENSP00000302599
  • ENSG00000172461

Symbol
  • Fuc-TIX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
virus perturbation
0.9
kinase perturbation
0.76
PubMedID
0.72
microRNA
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.79   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.79   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.998774711
p_ni:  0.001225151
p_wrong:  1.37e-7
Score:  0.234
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.799826496
p_ni:  0.200173504
Score:  0.161
Data Source:  BioPlex,STRINGDB
FUT1
Tbio
Family:  Enzyme
Novelty:  0.00597206
Score:  0.968
Data Source:  STRINGDB
FUT2
Tbio
Family:  Enzyme
Novelty:  0.0009286
Score:  0.959
Data Source:  STRINGDB
ST3GAL6
Tbio
Family:  Enzyme
Novelty:  0.05226811
Score:  0.959
Data Source:  STRINGDB
B4GALT1
Tbio
Family:  Enzyme
Novelty:  0.0073693
Score:  0.945
Data Source:  STRINGDB
B4GALT2
Tbio
Family:  Enzyme
Novelty:  0.03492512
Score:  0.942
Data Source:  STRINGDB
B4GALT3
Tbio
Family:  Enzyme
Novelty:  0.04015046
Score:  0.935
Data Source:  STRINGDB
GCNT2
Tbio
Family:  Enzyme
Novelty:  0.03945461
Score:  0.918
Data Source:  STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Blood group systems biosynthesis (R-HSA-9033658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
2
2
39.6
biological sex
1
1
1
26.1
5
1
2
1.2
8.1
intelligence
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
39.6
biological sex
1
26.1
2
1.2
8.1
intelligence
1
5.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
fucosyltransferase 9
708361
Mouse
MGI:1330859
14348
Rat
RGD:619955
84597
Dog
fucosyltransferase 9
VGNC:41016
449027
Horse
fucosyltransferase 9
VGNC:18160
100071396
Species
Name
OMA
EggNOG
Inparanoid
Macaque
fucosyltransferase 9
Mouse
Rat
Dog
fucosyltransferase 9
Horse
fucosyltransferase 9
Publication Statistics
PubMed Score 37.79
PubMed score by year
PubTator Score 23.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title