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Tchem
FUT7
Alpha-(1,3)-fucosyltransferase 7

Protein Summary
Description
Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens. The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314412
  • ENSP00000318142
  • ENSG00000180549

Symbol
  • FucT-VII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.81
tissue sample
0.73
cellular component
0.69
biological process
0.54
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.19   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.19   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (65)
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.98907021
p_ni:  0.01092979
Data Source:  BioPlex
YTHDF1
Tbio
Novelty:  0.02063275
p_int:  0.861672174
p_ni:  0.138327441
p_wrong:  3.84e-7
Data Source:  BioPlex
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.766615234
p_ni:  0.233384765
p_wrong:  1e-9
Data Source:  BioPlex
ST3GAL6
Tbio
Family:  Enzyme
Novelty:  0.05226811
Score:  0.965
Data Source:  STRINGDB
ST8SIA1
Tbio
Family:  Enzyme
Novelty:  0.02322808
Score:  0.954
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.896
Data Source:  STRINGDB
SELPLG
Tbio
Novelty:  0.0016359
Score:  0.85
Data Source:  STRINGDB
FUT4
Tbio
Family:  Enzyme
Novelty:  0.00060869
Score:  0.82
Data Source:  STRINGDB
SELL
Tchem
Novelty:  0.00030025
Score:  0.761
Data Source:  STRINGDB
NPDC1
Tbio
Novelty:  0.05766647
Score:  0.745
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Blood group systems biosynthesis (R-HSA-9033658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
6
6
91.7
central corneal thickness
3
2
0
2.9
84
monocyte percentage of leukocytes
2
2
2
78.5
lymphocyte count
2
2
3
68.7
renal system measurement
1
1
1
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
6
91.7
central corneal thickness
0
2.9
84
monocyte percentage of leukocytes
2
78.5
lymphocyte count
3
68.7
renal system measurement
1
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107692
14347
Rat
RGD:735019
296564
Dog
fucosyltransferase 7
VGNC:41014
449026
Horse
fucosyltransferase 7
VGNC:18158
100067846
Cow
fucosyltransferase 7
VGNC:29151
100036592
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
fucosyltransferase 7
Horse
fucosyltransferase 7
Cow
fucosyltransferase 7
Publication Statistics
PubMed Score 93.19
PubMed score by year
PubTator Score 80.55
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title