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Tbio
FUT4
Alpha-(1,3)-fucosyltransferase 4

Protein Summary
Description
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens. The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358752
  • ENSP00000351602
  • ENSG00000196371

Symbol
  • ELFT
  • FCT3A
  • LeX
  • CD15
  • ELFT
  • FCT3A
  • FUTIV
  • SSEA-1
  • FUC-TIV
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
PubMedID
0.85
virus perturbation
0.83
disease perturbation
0.68
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1598.7   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 1626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1598.7   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 1626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
HFE
Tbio
Novelty:  0.00042077
p_int:  0.999986502
p_ni:  0.000011231
p_wrong:  0.000002267
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999724588
p_ni:  0.000060325
p_wrong:  0.000215087
Score:  0.433
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.999565448
p_ni:  0.00000992
p_wrong:  0.000424632
Score:  0.2
Data Source:  BioPlex,STRINGDB
ST3GAL6
Tbio
Family:  Enzyme
Novelty:  0.05226811
Score:  0.974
Data Source:  STRINGDB
FUT1
Tbio
Family:  Enzyme
Novelty:  0.00597206
Score:  0.971
Data Source:  STRINGDB
FUT2
Tbio
Family:  Enzyme
Novelty:  0.0009286
Score:  0.97
Data Source:  STRINGDB
ST8SIA1
Tbio
Family:  Enzyme
Novelty:  0.02322808
Score:  0.932
Data Source:  STRINGDB
GCNT2
Tbio
Family:  Enzyme
Novelty:  0.03945461
Score:  0.923
Data Source:  STRINGDB
B3GNT3
Tbio
Family:  Enzyme
Novelty:  0.04325325
Score:  0.92
Data Source:  STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Blood group systems biosynthesis (R-HSA-9033658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 4
VGNC:3125
449507
Mouse
MGI:95594
14345
Rat
RGD:619954
60670
Cow
fucosyltransferase 4
VGNC:29150
282854
Pig
fucosyltransferase 4
100513419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 4
Mouse
Rat
Cow
fucosyltransferase 4
Pig
fucosyltransferase 4
Publication Statistics
PubMed Score 1598.70
PubMed score by year
PubTator Score 910.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title