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Tbio
FUT3
Galactoside 3(4)-L-fucosyltransferase

Protein Summary
Description
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303225
  • ENSP00000305603
  • ENSG00000171124
  • ENST00000458379
  • ENSP00000416443
  • ENST00000589620
  • ENSP00000465804
  • ENST00000589918
  • ENSP00000468123

Symbol
  • FT3B
  • LE
  • LE
  • Les
  • FT3B
  • CD174
  • FucT-III
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.78
virus perturbation
0.68
biological term
0.59
disease
0.59
pathway
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.83   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 415   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.83   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 415   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
P10314
Tbio
Novelty:  0.00270731
p_int:  0.999868899
p_ni:  0.000131101
Data Source:  BioPlex
HAPLN3
Tbio
Novelty:  0.19545048
p_int:  0.995969693
p_ni:  0.001362138
p_wrong:  0.002668169
Score:  0.179
Data Source:  BioPlex,STRINGDB
C1QL1
Tdark
Novelty:  0.11689088
p_int:  0.982504423
p_ni:  0.017276217
p_wrong:  0.00021936
Data Source:  BioPlex
GLB1L2
Tdark
Family:  Enzyme
Novelty:  1.03866932
p_int:  0.966867607
p_ni:  0.033132393
Data Source:  BioPlex
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.963650486
p_ni:  0.036348914
p_wrong:  6e-7
Data Source:  BioPlex
HYAL2
Tbio
Family:  Enzyme
Novelty:  0.00740331
p_int:  0.958980065
p_ni:  0.008750375
p_wrong:  0.03226956
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZDHHC17
Tbio
Family:  Enzyme
Novelty:  0.03288707
p_int:  0.94863928
p_ni:  0.05136072
Score:  0.337
Data Source:  BioPlex,STRINGDB
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.936618487
p_ni:  0.063375738
p_wrong:  0.000005776
Data Source:  BioPlex
CNNM1
Tdark
Novelty:  0.11053515
p_int:  0.935955286
p_ni:  0.035558316
p_wrong:  0.028486398
Score:  0.162
Data Source:  BioPlex,STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
p_int:  0.909681053
p_ni:  0.090318947
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
4
4
8
97.1
cancer biomarker measurement
1
3
4
97
cancer antigen 19.9 measurement
1
2
2
91
vitamin B12 measurement
2
3
2
49.8
88.8
N-glycan measurement
2
1
18
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heart rate variability measurement
8
97.1
cancer biomarker measurement
4
97
cancer antigen 19.9 measurement
2
91
vitamin B12 measurement
2
49.8
88.8
N-glycan measurement
18
79.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 3
VGNC:6625
493975
Macaque
galactoside 3(4)-L-fucosyltransferase
697582
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 3
Macaque
galactoside 3(4)-L-fucosyltransferase
Publication Statistics
PubMed Score 164.83
PubMed score by year
PubTator Score 227.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title