Tbio FUT2 Galactoside 2-alpha-L-fucosyltransferase 2

Protein Summary

Description

Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q10981
• Q0VAG5
• Q14338
• Q5D0G2

Gene Name

• FUT2

Ensembl ID

• ENST00000391876
• ENSP00000375748
• ENSG00000176920
• ENST00000425340
• ENSP00000387498

Symbol

• SEC2
• SE
• Se2
• sej
• SEC2
• B12QTL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
kinase perturbation	0.81
phenotype	0.78
cellular component	0.74
disease	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Galactoside 2-alpha-l-fucosyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Galactoside 2-alpha-l-fucosyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.43   (req: < 5)

Gene RIFs: 110   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.43   (req: >= 5)

Gene RIFs: 110   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0