Tbio FUS RNA-binding protein FUS

Protein Summary

Description

Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• P35637
• Q9H4A8

Gene Name

• FUS

Ensembl ID

• ENST00000254108
• ENSP00000254108
• ENSG00000089280
• ENST00000380244
• ENSP00000369594

Symbol

• TLS
• TLS
• ALS6
• ETM4
• FUS1
• POMP75
• HNRNPP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
interacting protein	1
transcription factor perturbation	0.97
hub protein	0.94
transcription factor binding site profile	0.92

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Rna-binding Protein Fus

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Rna-binding Protein Fus

Protein / Nucleic Acid Binding / Dna Binding Protein / Rna-binding Protein Fus

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Rna-binding Protein Fus

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2066.58   (req: < 5)

Gene RIFs: 437   (req: <= 3)

Antibodies: 401   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2066.58   (req: >= 5)

Gene RIFs: 437   (req: > 3)

Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0