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Tbio
FUS
RNA-binding protein FUS

Protein Summary
Description
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity. This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254108
  • ENSP00000254108
  • ENSG00000089280
  • ENST00000380244
  • ENSP00000369594

Symbol
  • TLS
  • TLS
  • ALS6
  • ETM4
  • FUS1
  • POMP75
  • HNRNPP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
transcription factor perturbation
0.97
hub protein
0.94
transcription factor binding site profile
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1693.91   (req: < 5)
Gene RIFs: 278   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1693.91   (req: >= 5)
Gene RIFs: 278   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (366)
KCTD6
Tbio
Novelty:  0.43478298
p_int:  0.998283177
p_ni:  0.001513672
p_wrong:  0.000203151
Score:  0.197
Data Source:  BioPlex,STRINGDB
RPS27
Tchem
Novelty:  0.02805495
p_int:  0.953949745
p_ni:  0.046050255
Score:  0.211
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.818553948
p_ni:  0.181446052
Score:  0.507
Data Source:  BioPlex,STRINGDB
PSRC1
Tbio
Novelty:  0.02780308
p_int:  0.786001163
p_ni:  0.213998837
Score:  0.38
Data Source:  BioPlex,STRINGDB
SMCO3
Tdark
Novelty:  5.91111111
p_int:  0.768332721
p_ni:  0.231667279
Score:  0.359
Data Source:  BioPlex,STRINGDB
CDC5L
Tbio
Family:  TF
Novelty:  0.00663599
Score:  0.998
Data Source:  STRINGDB
HNRNPD
Tbio
Novelty:  0.00538829
Score:  0.991
Data Source:  STRINGDB
TNPO1
Tbio
Novelty:  0.01278619
Score:  0.987
Data Source:  STRINGDB
SRSF10
Tbio
Novelty:  0.01273022
Score:  0.982
Data Source:  STRINGDB
HNRNPA3
Tbio
Novelty:  0.03214786
Score:  0.98
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
0
1.7
98.1
IGF-1 measurement
1
4
4
86.5
waist circumference
2
2
2
67.4
serum non-albumin protein measurement
1
2
2
66.8
body fat distribution
1
1
3
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
98.1
IGF-1 measurement
4
86.5
waist circumference
2
67.4
serum non-albumin protein measurement
2
66.8
body fat distribution
3
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1353633
233908
Rat
RGD:1308864
317385
Dog
FUS RNA binding protein
VGNC:41011
100856381
Cow
FUS RNA binding protein
VGNC:29147
280796
Pig
FUS RNA binding protein
100522185
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
FUS RNA binding protein
Cow
FUS RNA binding protein
Pig
FUS RNA binding protein
Publication Statistics
PubMed Score 1693.91
PubMed score by year
PubTator Score 790.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title