Protein Summary
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then s ...more
- ENST00000268171
- ENSP00000268171
- ENSG00000140564
- ENST00000610579
- ENSP00000484952
- ENST00000618099
- ENSP00000483552
- FUR
- PACE
- PCSK3
- FUR
- PACE
- SPC1
- PCSK3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
biological process | 0.93 | ||
molecular function | 0.91 | ||
cellular component | 0.88 | ||
hub protein | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1744.52 (req: < 5)
Gene RIFs: 122 (req: <= 3)
Antibodies: 394 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1744.52 (req: >= 5)
Gene RIFs: 122 (req: > 3)
Antibodies: 394 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 35
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 186
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (186)
Protein-Protein Interactions (264)
MPRIP
Family: Enzyme
Novelty: 0.03253403
p_int: 0.999969667
p_ni: 0.000030333
p_wrong: 1e-9
Data Source: BioPlex
SCPEP1
Family: Enzyme
Novelty: 0.08603794
p_int: 0.999949502
p_ni: 0.000050493
p_wrong: 5e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
PPP1R10
Family: Enzyme
Novelty: 0.01119155
p_int: 0.999839567
p_ni: 0.000160433
Data Source: BioPlex
ZC3H4
Novelty: 0.14897433
p_int: 0.999726741
p_ni: 0.000272185
p_wrong: 0.000001074
Data Source: BioPlex
LEMD3
Novelty: 0.00579701
p_int: 0.999418037
p_ni: 0.000581961
p_wrong: 2e-9
Data Source: BioPlex
SERPINA5
Family: Enzyme
Novelty: 0.00152504
p_int: 0.999268525
p_ni: 0.000731409
p_wrong: 6.6e-8
Score: 0.446
Data Source: BioPlex,STRINGDB
ATE1
Family: Enzyme
Novelty: 0.01672896
p_int: 0.999010489
p_ni: 0.000989512
Data Source: BioPlex
RHOBTB3
Novelty: 0.09149494
p_int: 0.99495582
p_ni: 0.005044
p_wrong: 1.8e-7
Data Source: BioPlex
SERPINE2
Novelty: 0.00246375
p_int: 0.994270975
p_ni: 0.005729009
p_wrong: 1.6e-8
Score: 0.256
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (54)
Reactome (40)
PathwayCommons (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of Matrix Metalloproteinases | ||||
Reactome | Amyloid fiber formation | ||||
Reactome | Assembly Of The HIV Virion | ||||
Reactome | Assembly of active LPL and LIPC lipase complexes | ||||
Reactome | Collagen degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of Matrix Metalloproteinases | ||||
Amyloid fiber formation | ||||
Assembly Of The HIV Virion | ||||
Assembly of active LPL and LIPC lipase complexes | ||||
Collagen degradation | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (8)
Components (13)
Processes (27)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 5 | 6 | 99.2 | |||||
7 | 6 | 4 | 1.1 | 96 | |||||
8 | 4 | 4 | 1.1 | 94.2 | |||||
mean platelet volume | 3 | 2 | 3 | 93.3 | |||||
birth weight | 4 | 4 | 4 | 90 | |||||
Items per page:
1 – 5 of 38
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 6 | 99.2 | |||||
4 | 1.1 | 96 | |||||
4 | 1.1 | 94.2 | |||||
mean platelet volume | 3 | 93.3 | |||||
birth weight | 4 | 90 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | furin, paired basic amino acid cleaving enzyme | VGNC:7766 | 453652 | |||||
Macaque | furin, paired basic amino acid cleaving enzyme | 715813 | ||||||
Mouse | MGI:97513 | 18550 | ||||||
Rat | RGD:3274 | 54281 | ||||||
Dog | furin, paired basic amino acid cleaving enzyme | VGNC:41010 | 488746 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | furin, paired basic amino acid cleaving enzyme | |||||
Macaque | furin, paired basic amino acid cleaving enzyme | |||||
Mouse | ||||||
Rat | ||||||
Dog | furin, paired basic amino acid cleaving enzyme | |||||
Publication Statistics
PubMed Score 1744.52
PubMed score by year
PubTator Score 1027.35
PubTator score by year
Related Publications
Text Mined References (204)
GeneRif Annotations (122)
Items per page:
0 of 0
PMID | Year | Title |
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