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Tchem
FURIN
Furin

Protein Summary
Description
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268171
  • ENSP00000268171
  • ENSG00000140564
  • ENST00000610579
  • ENSP00000484952
  • ENST00000618099
  • ENSP00000483552

Symbol
  • FUR
  • PACE
  • PCSK3
  • FUR
  • PACE
  • SPC1
  • PCSK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.93
molecular function
0.91
cellular component
0.88
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2335.33   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2335.33   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 289
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (289)
CHEMBL3126388
Rendered image for CHEMBL3126388
CHEMBL568525
Rendered image for CHEMBL568525
CHEMBL3115771
Rendered image for CHEMBL3115771
CHEMBL3115770
Rendered image for CHEMBL3115770
CHEMBL569918
Rendered image for CHEMBL569918
CHEMBL569280
Rendered image for CHEMBL569280
CHEMBL568067
Rendered image for CHEMBL568067
CHEMBL1645024
Rendered image for CHEMBL1645024
CHEMBL4065072
Rendered image for CHEMBL4065072
Protein-Protein Interactions (264)
MPRIP
Tbio
Family:  Enzyme
Novelty:  0.03253403
p_int:  0.999969667
p_ni:  0.000030333
p_wrong:  1e-9
Data Source:  BioPlex
SCPEP1
Tbio
Family:  Enzyme
Novelty:  0.08603794
p_int:  0.999949502
p_ni:  0.000050493
p_wrong:  5e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
PPP1R10
Tbio
Family:  Enzyme
Novelty:  0.01119155
p_int:  0.999839567
p_ni:  0.000160433
Data Source:  BioPlex
ZC3H4
Tbio
Novelty:  0.14897433
p_int:  0.999726741
p_ni:  0.000272185
p_wrong:  0.000001074
Data Source:  BioPlex
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.999418037
p_ni:  0.000581961
p_wrong:  2e-9
Data Source:  BioPlex
SERPINA5
Tbio
Family:  Enzyme
Novelty:  0.00152504
p_int:  0.999268525
p_ni:  0.000731409
p_wrong:  6.6e-8
Score:  0.446
Data Source:  BioPlex,STRINGDB
ATE1
Tbio
Family:  Enzyme
Novelty:  0.01672896
p_int:  0.999010489
p_ni:  0.000989512
Data Source:  BioPlex
SAFB
Tbio
Novelty:  0.01750671
p_int:  0.995516788
p_ni:  0.004483207
p_wrong:  5e-9
Data Source:  BioPlex
RHOBTB3
Tbio
Novelty:  0.09149494
p_int:  0.99495582
p_ni:  0.005044
p_wrong:  1.8e-7
Data Source:  BioPlex
SERPINE2
Tbio
Novelty:  0.00246375
p_int:  0.994270975
p_ni:  0.005729009
p_wrong:  1.6e-8
Score:  0.256
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

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Find Similar Targets
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Amyloid fiber formation
Reactome
Assembly Of The HIV Virion
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Collagen degradation
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Amyloid fiber formation
Assembly Of The HIV Virion
Assembly of active LPL and LIPC lipase complexes
Collagen degradation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (57)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
5
1.1
98.6
type 2 diabetes mellitus
9
4
5
1.1
98.3
red blood cell distribution width
4
5
6
96.1
diastolic blood pressure
4
2
4
95.2
birth weight
4
4
4
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
98.6
type 2 diabetes mellitus
5
1.1
98.3
red blood cell distribution width
6
96.1
diastolic blood pressure
4
95.2
birth weight
4
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
furin, paired basic amino acid cleaving enzyme
VGNC:7766
453652
Macaque
furin, paired basic amino acid cleaving enzyme
715813
Mouse
MGI:97513
18550
Rat
RGD:3274
54281
Dog
furin, paired basic amino acid cleaving enzyme
VGNC:41010
488746
Species
Name
OMA
EggNOG
Inparanoid
Chimp
furin, paired basic amino acid cleaving enzyme
Macaque
furin, paired basic amino acid cleaving enzyme
Mouse
Rat
Dog
furin, paired basic amino acid cleaving enzyme
Publication Statistics
PubMed Score 2335.33
PubMed score by year
PubTator Score 1027.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title