Tbio FUOM Fucose mutarotase

Protein Summary

Description

Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

Uniprot Accession IDs

• A2VDF0
• A1L300
• Q5VWY2
• Q5VWY3
• Q6ZPD2

Gene Name

• FUOM

Ensembl ID

• ENST00000278025
• ENSP00000278025
• ENSG00000148803
• ENST00000368552
• ENSP00000357540

Symbol

• C10orf125
• FUCU
• FucM
• C10orf125

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.84
tissue sample	0.68
tissue	0.54
transcription factor perturbation	0.54
virus perturbation	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0