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Tbio
FUOM
Fucose mutarotase

Protein Summary
Description
Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278025
  • ENSP00000278025
  • ENSG00000148803
  • ENST00000368552
  • ENSP00000357540

Symbol
  • C10orf125
  • FUCU
  • FucM
  • C10orf125
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
tissue sample
0.68
tissue
0.54
transcription factor perturbation
0.54
virus perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.9   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.999959307
p_wrong:  0.000040693
Data Source:  BioPlex
AFDN
Tbio
Novelty:  0.00372947
p_int:  0.982490641
p_ni:  0.017509351
p_wrong:  8e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
EEA1
Tbio
Novelty:  0.00242832
p_int:  0.982050457
p_ni:  0.017949543
Score:  0.165
Data Source:  BioPlex,STRINGDB
PRRC1
Tdark
Novelty:  0.49313765
p_int:  0.94066988
p_ni:  0.059322649
p_wrong:  0.000007471
Score:  0.189
Data Source:  BioPlex,STRINGDB
TOMM34
Tbio
Novelty:  0.05433718
p_int:  0.936024685
p_ni:  0.06397528
p_wrong:  3.6e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
FRA10AC1
Tbio
Novelty:  0.25570773
p_int:  0.93176965
p_ni:  0.067451344
p_wrong:  0.000779006
Score:  0.19
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.924918579
p_ni:  0.075081419
p_wrong:  2e-9
Data Source:  BioPlex
GPALPP1
Tdark
Novelty:  13.22858591
p_int:  0.923256764
p_ni:  0.076595077
p_wrong:  0.000148159
Score:  0.179
Data Source:  BioPlex,STRINGDB
GOLGA3
Tbio
Novelty:  0.03018438
p_int:  0.919678342
p_ni:  0.080321658
Score:  0.177
Data Source:  BioPlex,STRINGDB
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
p_int:  0.916963256
p_ni:  0.082925467
p_wrong:  0.000111277
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
GDP-fucose biosynthesis
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
GDP-fucose biosynthesis
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
1
1
80.3
blood metabolite measurement
1
1
1
65.3
longevity
1
1
0
3.5
61.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
80.3
blood metabolite measurement
1
65.3
longevity
0
3.5
61.6
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucose mutarotase
VGNC:3860
450853
Macaque
fucose mutarotase
719873
Mouse
MGI:1916314
69064
Rat
RGD:1311186
293587
Dog
fucose mutarotase
VGNC:41009
491696
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucose mutarotase
Macaque
fucose mutarotase
Mouse
Rat
Dog
fucose mutarotase
Publication Statistics
PubMed Score 19.90
PubMed score by year
PubTator Score 5.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title