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Tbio
FUK
L-fucose kinase

Protein Summary
Description
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides. The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000288078
  • ENSP00000288078
  • ENSG00000157353
  • ENST00000378912
  • ENSP00000368192

Symbol
  • FUK
  • CDGF2
  • 1110046B12Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
molecular function
0.88
protein domain
0.85
kinase perturbation
0.71
virus perturbation
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
p_int:  0.998605781
p_ni:  0.000144463
p_wrong:  0.001249756
Score:  0.187
Data Source:  BioPlex,STRINGDB
PRKCSH
Tbio
Family:  Enzyme
Novelty:  0.00787916
p_int:  0.995177697
p_ni:  0.000171275
p_wrong:  0.004651028
Score:  0.314
Data Source:  BioPlex,STRINGDB
C10orf91
Tdark
p_int:  0.9776481
p_ni:  0.015601481
p_wrong:  0.006750419
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.976439136
p_ni:  0.023560865
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.976268016
p_ni:  0.008501812
p_wrong:  0.015230172
Data Source:  BioPlex
HSPA1L
Tbio
Novelty:  0.01658161
p_int:  0.944487666
p_ni:  0.055512334
Data Source:  BioPlex
PPDPFL
Tdark
Novelty:  3.16137791
p_int:  0.905790562
p_ni:  0.088716126
p_wrong:  0.005493312
Data Source:  BioPlex
HSPA6
Tbio
Novelty:  0.00654285
p_int:  0.893354618
p_ni:  0.106645382
Data Source:  BioPlex
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.846649971
p_ni:  0.153350029
Data Source:  BioPlex
FPGT
Tbio
Family:  Enzyme
Novelty:  0.05687992
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
GDP-fucose biosynthesis
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
GDP-fucose biosynthesis
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
32.3
total cholesterol measurement
1
1
1
22.8
low density lipoprotein cholesterol measurement
2
1
2
15.1
phospholipids:total lipids ratio
1
1
1
15.1
cholesteryl esters:total lipids ratio
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
32.3
total cholesterol measurement
1
22.8
low density lipoprotein cholesterol measurement
2
15.1
phospholipids:total lipids ratio
1
15.1
cholesteryl esters:total lipids ratio
1
15.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucokinase
VGNC:5774
468015
Macaque
fucokinase
709226
Mouse
MGI:1916071
234730
Rat
RGD:1307000
307848
Dog
fucokinase
VGNC:41006
489715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucokinase
Macaque
fucokinase
Mouse
Rat
Dog
fucokinase
Publication Statistics
PubMed Score 52.53
PubMed score by year
PubTator Score 7.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title