You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FTSJ3
pre-rRNA processing protein FTSJ3

Protein Summary
Description
Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427159
  • ENSP00000396673
  • ENSG00000108592

Symbol
  • SPB1
  • EPCS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.95
transcription factor binding site profile
0.88
drug perturbation
0.87
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.06   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.06   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (375)
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.989680838
p_ni:  0.010319162
Score:  0.991
Data Source:  BioPlex,STRINGDB
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.972700071
p_ni:  0.027299929
Score:  0.782
Data Source:  BioPlex,STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.968531488
p_ni:  0.031468512
Score:  0.4
Data Source:  BioPlex,STRINGDB
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.96819689
p_ni:  0.03180311
Score:  0.353
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.950371088
p_ni:  0.049628912
Score:  0.173
Data Source:  BioPlex,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.935436769
p_ni:  0.06456323
Data Source:  BioPlex
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.933943926
p_ni:  0.066056074
Score:  0.655
Data Source:  BioPlex,STRINGDB
RPL14
Tbio
Novelty:  0.01600377
p_int:  0.930270773
p_ni:  0.069729227
Score:  0.65
Data Source:  BioPlex,STRINGDB
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.926085536
p_ni:  0.073914464
Score:  0.998
Data Source:  BioPlex,STRINGDB
NOL12
Tbio
Novelty:  0.15925205
p_int:  0.924277372
p_ni:  0.075722628
Score:  0.831
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
98.4
body height
7
6
8
97.2
appendicular lean mass
2
3
6
96.8
BMI-adjusted hip circumference
3
5
6
92.3
hematocrit
2
2
2
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
98.4
body height
8
97.2
appendicular lean mass
6
96.8
BMI-adjusted hip circumference
6
92.3
hematocrit
2
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FtsJ RNA methyltransferase homolog 3
VGNC:9299
454778
Macaque
FtsJ RNA methyltransferase homolog 3
718009
Mouse
MGI:1860295
56095
Rat
RGD:1307110
303608
Dog
FtsJ RNA methyltransferase homolog 3
VGNC:41004
490911
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FtsJ RNA methyltransferase homolog 3
Macaque
FtsJ RNA methyltransferase homolog 3
Mouse
Rat
Dog
FtsJ RNA methyltransferase homolog 3
Publication Statistics
PubMed Score 56.06
PubMed score by year
PubTator Score 20.92
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title