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Tchem
FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

Protein Summary
Description
RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000431610
  • ENSP00000415636
  • ENSG00000140718
  • ENST00000460382
  • ENSP00000417422
  • ENST00000463855
  • ENSP00000417843
  • ENST00000471389
  • ENSP00000418823

Symbol
  • KIAA1752
  • GDFD
  • ALKBH9
  • BMIQ14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
trait
1
disease perturbation
0.93
histone modification site profile
0.84
disease
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2228.91   (req: < 5)
Gene RIFs: 589   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2228.91   (req: >= 5)
Gene RIFs: 589   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (168)
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.998979583
p_ni:  0.001020416
p_wrong:  1e-9
Data Source:  BioPlex
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.991856362
p_ni:  0.008143638
Data Source:  BioPlex
GPX7
Tbio
Family:  Enzyme
Novelty:  0.01342855
p_int:  0.984318267
p_ni:  0.015655982
p_wrong:  0.000025751
Data Source:  BioPlex
MPZL1
Tbio
Novelty:  0.03292508
p_int:  0.97563283
p_ni:  0.024367147
p_wrong:  2.3e-8
Data Source:  BioPlex
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.94866597
p_ni:  0.051314289
p_wrong:  0.000019741
Data Source:  BioPlex
ZMAT3
Tbio
Novelty:  0.04765896
p_int:  0.937657355
p_ni:  0.062264787
p_wrong:  0.000077858
Score:  0.513
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.936031329
p_ni:  0.06293592
p_wrong:  0.001032751
Score:  0.165
Data Source:  BioPlex,STRINGDB
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.927046543
p_ni:  0.072953091
p_wrong:  3.66e-7
Data Source:  BioPlex
FGB
Tbio
Novelty:  0.00437751
p_int:  0.925352522
p_ni:  0.074647478
Data Source:  BioPlex
OR5F1
Tdark
Family:  oGPCR
Novelty:  13
p_int:  0.918026942
p_ni:  0.081973058
Score:  0.189
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
DNA Damage Reversal (R-HSA-73942)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Reversal
Reactome
DNA Repair
Reactome
Reversal of alkylation damage by DNA dioxygenases
Name
Explore in Pharos
Explore in Source
DNA Damage Reversal
DNA Repair
Reversal of alkylation damage by DNA dioxygenases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (93)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
39
29
81
5.3
100
17
8
5
1.1
99.5
waist-hip ratio
5
6
9
99.1
anthropometric measurement
1
4
0
1.3
98.3
physical activity measurement
2
4
6
1
98.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
81
5.3
100
5
1.1
99.5
waist-hip ratio
9
99.1
anthropometric measurement
0
1.3
98.3
physical activity measurement
6
1
98.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FTO, alpha-ketoglutarate dependent dioxygenase
VGNC:14493
454090
Macaque
FTO, alpha-ketoglutarate dependent dioxygenase
703724
Mouse
MGI:1347093
26383
Rat
RGD:1305121
291905
Dog
FTO, alpha-ketoglutarate dependent dioxygenase
VGNC:41003
478125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FTO, alpha-ketoglutarate dependent dioxygenase
Macaque
FTO, alpha-ketoglutarate dependent dioxygenase
Mouse
Rat
Dog
FTO, alpha-ketoglutarate dependent dioxygenase
Publication Statistics
PubMed Score 2228.91
PubMed score by year
PubTator Score 1108.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title