Tbio FTL Ferritin light chain

Protein Summary

Description

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02792
• B2R4B9
• Q6IBT7
• Q7Z2W1
• Q86WI9
• Q8WU07
• Q96AU9
• Q96CU0
• Q9BTZ8
• Ferritin L subunit

Gene Name

• FTL

Ensembl ID

• ENST00000331825
• ENSP00000366525
• ENSG00000087086

Symbol

• LFTD
• NBIA3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
kinase perturbation	0.97
transcription factor binding site profile	0.96
transcription factor perturbation	0.94
disease perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Storage Protein / Ferritin Light Chain

DTO Classes

Protein / Storage / Ferritin Light Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.73   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 929   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 439.73   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 929   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (194)

Explore Interacting Targets

1 – 10 of 194

• See Interactions on String-DB

FTH1

Tbio

Novelty:  0.000863

p_int:  0.9999866

p_ni:  0.0000134

Score:  0.976

Data Source:  BioPlex,Reactome,STRINGDB

LUC7L

Tbio

Novelty:  0.05748021

p_int:  0.991964553

p_ni:  0.008035447

Score:  0.204

Data Source:  BioPlex,STRINGDB

NKAP

Tbio

Novelty:  0.04982584

p_int:  0.988833008

p_ni:  0.011166992

Score:  0.514

Data Source:  BioPlex,STRINGDB

SREK1IP1

Tdark

Novelty:  1.39429464

p_int:  0.986202193

p_ni:  0.013797807

Score:  0.392

Data Source:  BioPlex,STRINGDB

LUC7L2

Tdark

Novelty:  0.36989457

p_int:  0.985755216

p_ni:  0.014244784

Data Source:  BioPlex

NCOA4

Tbio

Novelty:  0.00487453

p_int:  0.981822336

p_ni:  0.01817764

p_wrong:  2.5e-8

Score:  0.957

Data Source:  BioPlex,STRINGDB

ZCCHC17

Tbio

Novelty:  0.06999007

p_int:  0.946900267

p_ni:  0.053099733

Score:  0.159

Data Source:  BioPlex,STRINGDB

ZNF263

Tbio

Family:  TF

Novelty:  0.098799

p_int:  0.907094069

p_ni:  0.09290593

p_wrong:  1e-9

Data Source:  BioPlex

ZNF558

Tdark

Family:  TF

Novelty:  0.821338

p_int:  0.822749059

p_ni:  0.177246919

p_wrong:  0.000004022

Score:  0.195

Data Source:  BioPlex,STRINGDB

NOP53

Tbio

Novelty:  0.00353077

p_int:  0.810054655

p_ni:  0.189915219

p_wrong:  0.000030125

Score:  0.436

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (31)

Reactome (11)

KEGG (3)

WikiPathways (17)

Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Reactome	Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Iron uptake and transport	59 targets	R-HSA-917937

Name	Explore in Pharos	Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors	116 targets	R-HSA-2173782
Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Iron uptake and transport	59 targets	R-HSA-917937

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (4)

Components (8)

Processes (6)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
iron ion binding	Inferred from Direct Assay (IDA)	UniProtKB
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
ferric iron binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ferrous iron binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (14)

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5

1 – 5 of 14

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	4	3	5		95.1
reticulocyte measurement	EFO_0010700	3	4	5		95
reticulocyte count	EFO_0007986	6	3	11		92.3
testosterone measurement	EFO_0004908	6	6	6		88
eosinophil count	EFO_0004842	3	1	3		70.9

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5

1 – 5 of 14

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
red blood cell distribution width	EFO_0005192	5		95.1
reticulocyte measurement	EFO_0010700	5		95
reticulocyte count	EFO_0007986	11		92.3
testosterone measurement	EFO_0004908	6		88
eosinophil count	EFO_0004842	3		70.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cataract
Complete proteome
Direct protein sequencing
Disease mutation
Iron
Iron storage
Metal-binding
Neurodegeneration

GWAS Trait Find Similar Targets

No Header	No Header
eosinophil count
eosinophil percentage of leukocytes
ferritin measurement
heel bone mineral density
leukocyte count
lymphocyte count
mean corpuscular hemoglobin concentration
neutrophil percentage of granulocytes
platelet crit
red blood cell distribution width

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
craniofacial phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
liver/biliary system phenotype
mortality/aging
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	ferritin light chain		718964
Mouse	ferritin light polypeptide 1	MGI:95589	14325
Cow	ferritin light chain		783993

Species	Name	OMA	EggNOG	Inparanoid
Macaque	ferritin light chain
Mouse	ferritin light polypeptide 1
Cow	ferritin light chain

Publication Statistics

PubMed Score 439.73

PubMed score by year

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PubTator Score 147.53

PubTator score by year

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Related Publications

Text Mined References (158)

GeneRif Annotations (92)

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0 of 0

PMID	Year	Title