Protein Summary
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
- ENST00000331825
- ENSP00000366525
- ENSG00000087086
- LFTD
- NBIA3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.97 | ||
kinase perturbation | 0.97 | ||
transcription factor binding site profile | 0.96 | ||
transcription factor perturbation | 0.94 | ||
disease perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 439.73 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 929 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 439.73 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 929 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (194)
FTH1
Novelty: 0.000863
p_int: 0.9999866
p_ni: 0.0000134
Score: 0.976
Data Source: BioPlex,Reactome,STRINGDB
LUC7L
Novelty: 0.05748021
p_int: 0.991964553
p_ni: 0.008035447
Score: 0.204
Data Source: BioPlex,STRINGDB
NKAP
Novelty: 0.04982584
p_int: 0.988833008
p_ni: 0.011166992
Score: 0.514
Data Source: BioPlex,STRINGDB
SREK1IP1
Novelty: 1.39429464
p_int: 0.986202193
p_ni: 0.013797807
Score: 0.392
Data Source: BioPlex,STRINGDB
NCOA4
Novelty: 0.00487453
p_int: 0.981822336
p_ni: 0.01817764
p_wrong: 2.5e-8
Score: 0.957
Data Source: BioPlex,STRINGDB
ZCCHC17
Novelty: 0.06999007
p_int: 0.946900267
p_ni: 0.053099733
Score: 0.159
Data Source: BioPlex,STRINGDB
ZNF263
Family: TF
Novelty: 0.098799
p_int: 0.907094069
p_ni: 0.09290593
p_wrong: 1e-9
Data Source: BioPlex
ZNF558
Family: TF
Novelty: 0.821338
p_int: 0.822749059
p_ni: 0.177246919
p_wrong: 0.000004022
Score: 0.195
Data Source: BioPlex,STRINGDB
NOP53
Novelty: 0.00353077
p_int: 0.810054655
p_ni: 0.189915219
p_wrong: 0.000030125
Score: 0.436
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (31)
Reactome (11)
KEGG (3)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | Golgi Associated Vesicle Biogenesis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Iron uptake and transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
Golgi Associated Vesicle Biogenesis | ||||
Immune System | ||||
Innate Immune System | ||||
Iron uptake and transport | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (4)
Components (8)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 3 | 5 | 95.1 | |||||
reticulocyte measurement | 3 | 4 | 5 | 95 | |||||
reticulocyte count | 6 | 3 | 11 | 92.3 | |||||
testosterone measurement | 6 | 6 | 6 | 88 | |||||
eosinophil count | 3 | 1 | 3 | 70.9 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
red blood cell distribution width | 5 | 95.1 | |||||
reticulocyte measurement | 5 | 95 | |||||
reticulocyte count | 11 | 92.3 | |||||
testosterone measurement | 6 | 88 | |||||
eosinophil count | 3 | 70.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | ferritin light chain | 718964 | ||||||
Mouse | MGI:95589 | 14325 | ||||||
Cow | ferritin light chain | 783993 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | ferritin light chain | |||||
Mouse | ||||||
Cow | ferritin light chain | |||||
Publication Statistics
PubMed Score 439.73
PubMed score by year
PubTator Score 147.53
PubTator score by year
Related Publications
Text Mined References (158)
GeneRif Annotations (92)
Items per page:
0 of 0
PMID | Year | Title |
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