Tbio FTH1 Ferritin heavy chain

Protein Summary

Description

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P02794
• B3KNR5
• Q3KRA8
• Q3SWW1
• Ferritin H subunit

Gene Name

• FTH1

Ensembl ID

• ENST00000273550
• ENSP00000273550
• ENSG00000167996
• ENST00000620041
• ENSP00000484477

Symbol

• FTH
• FTHL6
• FHC
• FTH
• HFE5
• PLIF
• FTHL6
• PIG15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
virus perturbation	0.99
transcription factor perturbation	0.94
transcription factor binding site profile	0.88

Protein Classes

PANTHER Classes

Protein / Storage Protein / Ferritin Heavy Chain

DTO Classes

Protein / Storage / Ferritin Heavy Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1361.59   (req: < 5)

Gene RIFs: 126   (req: <= 3)

Antibodies: 808   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1361.59   (req: >= 5)

Gene RIFs: 126   (req: > 3)

Antibodies: 808   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0