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Tbio
FTH1
Ferritin heavy chain

Protein Summary
Description
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273550
  • ENSP00000273550
  • ENSG00000167996
  • ENST00000620041
  • ENSP00000484477

Symbol
  • FTH
  • FTHL6
  • FHC
  • FTH
  • HFE5
  • PLIF
  • FTHL6
  • PIG15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
virus perturbation
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.88


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1164.77   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 808   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1164.77   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 808   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
RBP4
Tchem
Novelty:  0.00168442
p_int:  0.999997344
p_ni:  0.000002423
p_wrong:  2.33e-7
Score:  0.191
Data Source:  BioPlex,STRINGDB
SDR16C5
Tbio
Family:  Enzyme
Novelty:  0.11319496
p_int:  0.999996445
p_ni:  0.000003278
p_wrong:  2.77e-7
Score:  0.212
Data Source:  BioPlex,STRINGDB
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999988841
p_ni:  0.000011159
Data Source:  BioPlex
FTL
Tbio
Novelty:  0.00235168
p_int:  0.9999866
p_ni:  0.0000134
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.999986264
p_ni:  0.000013736
Data Source:  BioPlex
A2ML1
Tbio
Novelty:  0.05923067
p_int:  0.99998081
p_ni:  0.00001919
Data Source:  BioPlex
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
p_int:  0.999978097
p_ni:  0.000021903
Score:  0.152
Data Source:  BioPlex,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
p_int:  0.999922078
p_ni:  0.000031119
p_wrong:  0.000046803
Score:  0.151
Data Source:  BioPlex,STRINGDB
TREX2
Tbio
Family:  Enzyme
Novelty:  0.27214255
p_int:  0.999777166
p_ni:  0.000129759
p_wrong:  0.000093076
Data Source:  BioPlex
KLK10
Tbio
Family:  Enzyme
Novelty:  0.00899521
p_int:  0.999682273
p_ni:  0.000317726
p_wrong:  2e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Iron uptake and transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Golgi Associated Vesicle Biogenesis
Immune System
Innate Immune System
Iron uptake and transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
5
5
95.4
docosapentaenoic acid measurement
1
3
3
94.3
eicosapentaenoic acid measurement
1
4
4
92.1
triglyceride measurement
1
2
2
86.4
alpha-linolenic acid measurement
1
2
2
80.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
95.4
docosapentaenoic acid measurement
3
94.3
eicosapentaenoic acid measurement
4
92.1
triglyceride measurement
2
86.4
alpha-linolenic acid measurement
2
80.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ferritin, heavy polypeptide 1-like
714576
Mouse
MGI:95588
14319
Rat
RGD:2635
25319
Dog
ferritin, heavy polypeptide 1
403631
Horse
ferritin, heavy polypeptide 1
100062811
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ferritin, heavy polypeptide 1-like
Mouse
Rat
Dog
ferritin, heavy polypeptide 1
Horse
ferritin, heavy polypeptide 1
Publication Statistics
PubMed Score 1164.77
PubMed score by year
PubTator Score 384.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title