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Tbio
FSTL3
Follistatin-related protein 3

Protein Summary
Description
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000166139
  • ENSP00000166139
  • ENSG00000070404

Symbol
  • FLRG
  • FLRG
  • FSRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
transcription factor
0.64
gene perturbation
0.61
tissue sample
0.61
small molecule perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.38   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.38   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (146)
INHBA
Tbio
Novelty:  0.00657844
Score:  0.994
Data Source:  Reactome,STRINGDB
MSTN
Tclin
Novelty:  0.00062316
Score:  0.969
Data Source:  STRINGDB
FSTL1
Tbio
Novelty:  0.00557848
Score:  0.967
Data Source:  STRINGDB
INHBB
Tbio
Novelty:  0.0154773
Score:  0.947
Data Source:  Reactome,STRINGDB
FN1
Tchem
Novelty:  0.00003647
Score:  0.947
Data Source:  STRINGDB
BMP4
Tchem
Novelty:  0.00047387
Score:  0.943
Data Source:  STRINGDB
CHRDL1
Tbio
Novelty:  0.01748654
Score:  0.935
Data Source:  STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
Score:  0.923
Data Source:  STRINGDB
IGFBP7
Tbio
Novelty:  0.00249209
Score:  0.922
Data Source:  STRINGDB
QSOX1
Tbio
Family:  Enzyme
Novelty:  0.02152583
Score:  0.922
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Antagonism of Activin by Follistatin (R-HSA-2473224)

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Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antagonism of Activin by Follistatin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Antagonism of Activin by Follistatin
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
2
2
1
5.8
55.9
corneal resistance factor
1
1
1
44.7
prostate cancer
1
1
0
1.9
38.6
disease progression measurement
1
1
0
1.9
38.6
cognitive function measurement
2
1
2
36.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
worry measurement
1
5.8
55.9
corneal resistance factor
1
44.7
prostate cancer
0
1.9
38.6
disease progression measurement
0
1.9
38.6
cognitive function measurement
2
36.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follistatin like 3
VGNC:11108
455531
Mouse
MGI:1890391
83554
Rat
RGD:621811
114031
Dog
follistatin like 3
VGNC:40999
612399
Cow
follistatin like 3
VGNC:29136
515367
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follistatin like 3
Mouse
Rat
Dog
follistatin like 3
Cow
follistatin like 3
Publication Statistics
PubMed Score 133.38
PubMed score by year
PubTator Score 55.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title