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Tbio
FSTL1
Follistatin-related protein 1

Protein Summary
Description
May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity). This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295633
  • ENSP00000295633
  • ENSG00000163430
  • ENST00000424703
  • ENSP00000394355

Symbol
  • FRP
  • FRP
  • FSL1
  • OCC1
  • OCC-1
  • tsc36
  • MIR198
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
PubMedID
0.96
kinase perturbation
0.84
disease perturbation
0.83
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.16   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.16   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.986656026
p_ni:  0.013019457
p_wrong:  0.000324516
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.979714804
p_ni:  0.020284515
p_wrong:  6.81e-7
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.976381142
p_ni:  0.023223245
p_wrong:  0.000395613
Data Source:  BioPlex
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
p_int:  0.970833421
p_ni:  0.029032942
p_wrong:  0.000133638
Data Source:  BioPlex
IL12A
Tclin
Novelty:  0.05943184
p_int:  0.954127365
p_ni:  0.045871395
p_wrong:  0.00000124
Score:  0.163
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.938032281
p_ni:  0.061961145
p_wrong:  0.000006574
Data Source:  BioPlex
SGCA
Tbio
Novelty:  0.00442268
p_int:  0.934755572
p_ni:  0.065243924
p_wrong:  5.03e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
WNT10B
Tbio
Novelty:  0.00503163
p_int:  0.924745703
p_ni:  0.075254297
Score:  0.287
Data Source:  BioPlex,STRINGDB
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.92333098
p_ni:  0.076664233
p_wrong:  0.000004788
Data Source:  BioPlex
DNASE2B
Tbio
Family:  Enzyme
Novelty:  0.02506932
p_int:  0.922505293
p_ni:  0.074003289
p_wrong:  0.003491419
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follistatin like 1
VGNC:1822
745040
Macaque
follistatin like 1
713367
Mouse
MGI:102793
14314
Rat
RGD:68955
79210
Dog
follistatin like 1
VGNC:49898
608384
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follistatin like 1
Macaque
follistatin like 1
Mouse
Rat
Dog
follistatin like 1
Publication Statistics
PubMed Score 249.16
PubMed score by year
PubTator Score 88.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title