FSHB
Follitropin subunit beta
Protein Summary
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
- ENST00000254122
- ENSP00000254122
- ENSG00000131808
- ENST00000417547
- ENSP00000416606
- ENST00000533718
- ENSP00000433424
- HH24
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
biological process | 0.86 | ||
disease | 0.67 | ||
tissue | 0.66 | ||
gene perturbation | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.88 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 890 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 197.88 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 890 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (197)
Nearest Tclin Targets (10)
Downstream (10)
1 – 5 of 10
Pathways (28)
Reactome (11)
KEGG (4)
PathwayCommons (7)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (s) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Glycoprotein hormones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (s) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Glycoprotein hormones | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (1)
Components (4)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
menstrual cycle measurement | 2 | 2 | 2 | 81.7 | |||||
4 | 3 | 1 | 1.4 | 67.9 | |||||
testosterone measurement | 3 | 2 | 3 | 67.9 | |||||
body mass index | 1 | 1 | 1 | 60.2 | |||||
body height | 1 | 1 | 1 | 59 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
menstrual cycle measurement | 2 | 81.7 | |||||
1 | 1.4 | 67.9 | |||||
testosterone measurement | 3 | 67.9 | |||||
body mass index | 1 | 60.2 | |||||
body height | 1 | 59 | |||||
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IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | follicle stimulating hormone subunit beta | VGNC:6558 | 736618 | |||||
Mouse | MGI:95582 | 14308 | ||||||
Rat | RGD:2630 | 25447 | ||||||
Dog | follicle stimulating hormone subunit beta | VGNC:40996 | 485428 | |||||
Horse | follicle stimulating hormone beta subunit | 100033829 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | follicle stimulating hormone subunit beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | follicle stimulating hormone subunit beta | |||||
Horse | follicle stimulating hormone beta subunit | |||||
Publication Statistics
PubMed Score 197.88
PubMed score by year
PubTator Score 277.75
PubTator score by year
Related Publications
Text Mined References (95)
GeneRif Annotations (58)
Items per page:
0 of 0
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