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Tbio
FSHB
Follitropin subunit beta

Protein Summary
Description
Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254122
  • ENSP00000254122
  • ENSG00000131808
  • ENST00000417547
  • ENSP00000416606
  • ENST00000533718
  • ENSP00000433424

Symbol
  • HH24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.86
disease
0.67
tissue
0.66
gene perturbation
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.88   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 890   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 197.88   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 890   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (197)
FSHR
Tclin
Family:  GPCR
Novelty:  0.00123929
Score:  0.995
Data Source:  Reactome,STRINGDB
CGA
Tbio
Novelty:  0.00394017
Score:  0.988
Data Source:  Reactome,STRINGDB
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
Score:  0.965
Data Source:  STRINGDB
GHRHR
Tclin
Family:  GPCR
Novelty:  0.00637611
Score:  0.955
Data Source:  STRINGDB
LHCGR
Tclin
Family:  GPCR
Novelty:  0.00169974
Score:  0.954
Data Source:  STRINGDB
TSHB
Tbio
Novelty:  0.00194403
Score:  0.952
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.951
Data Source:  STRINGDB
GPHA2
Tbio
Novelty:  0.01057969
Score:  0.944
Data Source:  STRINGDB
INHA
Tbio
Novelty:  0.00168407
Score:  0.938
Data Source:  STRINGDB
INHBB
Tbio
Novelty:  0.0154773
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets (10)
Explore Nearest Tclin Targets
1 – 5 of 10
Pathways (28)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glycoprotein hormones
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glycoprotein hormones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
menstrual cycle measurement
2
2
2
81.7
4
3
1
1.4
67.9
testosterone measurement
3
2
3
67.9
body mass index
1
1
1
60.2
body height
1
1
1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
menstrual cycle measurement
2
81.7
1
1.4
67.9
testosterone measurement
3
67.9
body mass index
1
60.2
body height
1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
follicle stimulating hormone subunit beta
VGNC:6558
736618
Mouse
MGI:95582
14308
Rat
RGD:2630
25447
Dog
follicle stimulating hormone subunit beta
VGNC:40996
485428
Horse
follicle stimulating hormone beta subunit
100033829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
follicle stimulating hormone subunit beta
Mouse
Rat
Dog
follicle stimulating hormone subunit beta
Horse
follicle stimulating hormone beta subunit
Publication Statistics
PubMed Score 197.88
PubMed score by year
PubTator Score 277.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title