Tbio FSHB Follitropin subunit beta

Protein Summary

Description

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P01225
• A2TF08
• A5JVV3
• Q14D61

Gene Name

• FSHB

Ensembl ID

• ENST00000254122
• ENSP00000254122
• ENSG00000131808
• ENST00000417547
• ENSP00000416606
• ENST00000533718
• ENSP00000433424

Symbol

• HH24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	1
biological process	0.86
disease	0.67
tissue	0.66
gene perturbation	0.65

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Follitropin Subunit Beta

DTO Classes

Protein / Signaling / Hormone / Follitropin Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.84   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 890   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.84   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 890   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0