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Tbio
FSD2
Fibronectin type III and SPRY domain-containing protein 2

Protein Summary
Description
This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334574
  • ENSP00000335651
  • ENSG00000186628
  • ENST00000541889
  • ENSP00000444078

Symbol
  • SPRYD1
  • SPRYD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.61
virus perturbation
0.5
tissue
0.48
cell line
0.43


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
IFFO1
Tdark
Novelty:  0.38051741
p_int:  0.999997524
p_ni:  0.000002476
Data Source:  BioPlex
TACC1
Tbio
Novelty:  0.03556945
p_int:  0.999973706
p_ni:  0.000026294
p_wrong:  1e-9
Data Source:  BioPlex
LETM1
Tbio
Novelty:  0.01542461
p_int:  0.999858353
p_ni:  0.000141641
p_wrong:  6e-9
Data Source:  BioPlex
KCTD6
Tbio
Novelty:  0.43478298
p_int:  0.999840682
p_ni:  0.000159025
p_wrong:  2.92e-7
Data Source:  BioPlex
ESD
Tchem
Family:  Enzyme
Novelty:  0.00519384
p_int:  0.999822413
p_ni:  0.000177587
Score:  0.22
Data Source:  BioPlex,STRINGDB
SPAG5
Tbio
Novelty:  0.02392116
p_int:  0.999777352
p_ni:  0.000222648
Data Source:  BioPlex
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.999721455
p_ni:  0.000275424
p_wrong:  0.000003122
Data Source:  BioPlex
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999677598
p_ni:  0.000322402
Data Source:  BioPlex
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.998596806
p_ni:  0.001403194
Data Source:  BioPlex
MAP7D1
Tdark
Novelty:  0.43190333
p_int:  0.998461013
p_ni:  0.001538987
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
4
4
81.6
hip circumference
1
2
2
53.7
self reported educational attainment
1
1
1
47.7
cognitive function measurement
1
1
1
47.7
intelligence
2
2
0
5.7
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
4
81.6
hip circumference
2
53.7
self reported educational attainment
1
47.7
cognitive function measurement
1
47.7
intelligence
0
5.7
45.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III and SPRY domain containing 2
VGNC:7767
453595
Macaque
fibronectin type III and SPRY domain containing 2
693575
Mouse
MGI:2444310
244091
Rat
RGD:1305167
308779
Dog
fibronectin type III and SPRY domain containing 2
VGNC:40995
609716
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III and SPRY domain containing 2
Macaque
fibronectin type III and SPRY domain containing 2
Mouse
Rat
Dog
fibronectin type III and SPRY domain containing 2
Publication Statistics
PubMed Score 7.33
PubMed score by year
PubTator Score 2.03
PubTator score by year
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Related Publications
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PMID
Year
Title