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Tbio
FSD1
Fibronectin type III and SPRY domain-containing protein 1

Protein Summary
Description
May be involved in microtubule organization and stabilization. This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221856
  • ENSP00000221856
  • ENSG00000105255

Symbol
  • GLFND
  • MIR1
  • MIR1
  • GLFND
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
tissue sample
0.68
cellular component
0.65
gene perturbation
0.63
transcription factor
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.39   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.39   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
ARPIN
Tbio
Novelty:  0.18393143
p_int:  0.999936681
p_ni:  0.000056915
p_wrong:  0.000006404
Score:  0.158
Data Source:  BioPlex,STRINGDB
UBFD1
Tdark
Novelty:  0.81992541
p_int:  0.999857815
p_ni:  0.000012336
p_wrong:  0.000129849
Score:  0.188
Data Source:  BioPlex,STRINGDB
EFHD1
Tbio
Novelty:  0.00808906
p_int:  0.999856433
p_ni:  0.000143541
p_wrong:  2.7e-8
Score:  0.213
Data Source:  BioPlex,STRINGDB
UBLCP1
Tchem
Family:  Enzyme
Novelty:  0.14438023
p_int:  0.999842554
p_ni:  0.000107786
p_wrong:  0.00004966
Score:  0.193
Data Source:  BioPlex,STRINGDB
AIDA
Tbio
Novelty:  0.7243992
p_int:  0.9986703
p_ni:  0.001308298
p_wrong:  0.000021402
Score:  0.183
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.992914805
p_ni:  0.006840748
p_wrong:  0.000244447
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.988100199
p_ni:  7.26e-7
p_wrong:  0.011899075
Data Source:  BioPlex
CHAC2
Tbio
Family:  Enzyme
Novelty:  0.14706039
p_int:  0.986005579
p_ni:  0.000123387
p_wrong:  0.013871034
Score:  0.188
Data Source:  BioPlex,STRINGDB
LZIC
Tdark
Novelty:  0.34151594
p_int:  0.983701137
p_ni:  0.007434376
p_wrong:  0.008864487
Data Source:  BioPlex
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.982495629
p_ni:  0.017432075
p_wrong:  0.000072296
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-27 measurement
1
4
4
98.6
blood protein measurement
1
1
1
87.5
hematocrit
2
1
2
77
self reported educational attainment
1
1
1
69.4
smoking status measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-27 measurement
4
98.6
blood protein measurement
1
87.5
hematocrit
2
77
self reported educational attainment
1
69.4
smoking status measurement
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III and SPRY domain containing 1
VGNC:11230
101057699
Macaque
fibronectin type III and SPRY domain containing 1
721843
Mouse
MGI:1934858
240121
Dog
fibronectin type III and SPRY domain containing 1
VGNC:40993
476743
Horse
fibronectin type III and SPRY domain containing 1
VGNC:18141
100062912
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III and SPRY domain containing 1
Macaque
fibronectin type III and SPRY domain containing 1
Mouse
Dog
fibronectin type III and SPRY domain containing 1
Horse
fibronectin type III and SPRY domain containing 1
Publication Statistics
PubMed Score 30.39
PubMed score by year
PubTator Score 208.25
PubTator score by year
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Related Publications
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PMID
Year
Title