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Tchem
FSCN1
Fascin

Protein Summary
Description
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382361
  • ENSP00000371798
  • ENSG00000075618

Symbol
  • FAN1
  • HSN
  • SNL
  • HSN
  • SNL
  • p55
  • FAN1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
PubMedID
0.96
transcription factor binding site profile
0.94
hub protein
0.9
small molecule perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.26   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 738   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 481.26   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 738   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (138)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999999017
p_ni:  9.83e-7
Data Source:  BioPlex
CACNA1A
Tchem
Family:  IC
Novelty:  0.00069217
p_int:  0.999425584
p_ni:  5.6e-8
p_wrong:  0.000574361
Data Source:  BioPlex
LCP1
Tbio
Novelty:  0.0035357
Score:  0.972
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.97
Data Source:  STRINGDB
GSN
Tbio
Novelty:  0.00060852
Score:  0.947
Data Source:  STRINGDB
CNN2
Tbio
Novelty:  0.02486182
Score:  0.945
Data Source:  STRINGDB
SH3PXD2A
Tbio
Novelty:  0.0252753
Score:  0.923
Data Source:  STRINGDB
ESPN
Tbio
Novelty:  0.0035928
Score:  0.916
Data Source:  STRINGDB
LPXN
Tbio
Novelty:  0.00796678
Score:  0.9
Data Source:  STRINGDB
BIN2
Tbio
Novelty:  0.00952157
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (39)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
67.5
reticulocyte count
2
2
2
63.6
mean platelet volume
1
1
1
56.8
lymphocyte count
2
2
2
56.4
mathematical ability
2
2
2
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
67.5
reticulocyte count
2
63.6
mean platelet volume
1
56.8
lymphocyte count
2
56.4
mathematical ability
2
45.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fascin actin-bundling protein 1
VGNC:14014
463247
Macaque
fascin actin-bundling protein 1
100430727
Mouse
MGI:1352745
14086
Dog
fascin actin-bundling protein 1
VGNC:40990
489880
Horse
fascin actin-bundling protein 1
VGNC:51134
100146921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fascin actin-bundling protein 1
Macaque
fascin actin-bundling protein 1
Mouse
Dog
fascin actin-bundling protein 1
Horse
fascin actin-bundling protein 1
Publication Statistics
PubMed Score 481.26
PubMed score by year
PubTator Score 394.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title