Protein Summary
Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. ...more
- ENST00000382361
- ENSP00000371798
- ENSG00000075618
- FAN1
- HSN
- SNL
- HSN
- SNL
- p55
- FAN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.97 | ||
PubMedID | 0.96 | ||
transcription factor binding site profile | 0.94 | ||
hub protein | 0.9 | ||
small molecule perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 481.26 (req: < 5)
Gene RIFs: 141 (req: <= 3)
Antibodies: 738 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 481.26 (req: >= 5)
Gene RIFs: 141 (req: > 3)
Antibodies: 738 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (13)
Protein-Protein Interactions (138)
CACNA1A
Family: IC
Novelty: 0.00069217
p_int: 0.999425584
p_ni: 5.6e-8
p_wrong: 0.000574361
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (6)
Components (17)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 2 | 2 | 67.5 | |||||
reticulocyte count | 2 | 2 | 2 | 63.6 | |||||
mean platelet volume | 1 | 1 | 1 | 56.8 | |||||
lymphocyte count | 2 | 2 | 2 | 56.4 | |||||
mathematical ability | 2 | 2 | 2 | 45.6 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 67.5 | |||||
reticulocyte count | 2 | 63.6 | |||||
mean platelet volume | 1 | 56.8 | |||||
lymphocyte count | 2 | 56.4 | |||||
mathematical ability | 2 | 45.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fascin actin-bundling protein 1 | VGNC:14014 | 463247 | |||||
Macaque | fascin actin-bundling protein 1 | 100430727 | ||||||
Mouse | MGI:1352745 | 14086 | ||||||
Dog | fascin actin-bundling protein 1 | VGNC:40990 | 489880 | |||||
Horse | fascin actin-bundling protein 1 | VGNC:51134 | 100146921 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | fascin actin-bundling protein 1 | |||||
Macaque | fascin actin-bundling protein 1 | |||||
Mouse | ||||||
Dog | fascin actin-bundling protein 1 | |||||
Horse | fascin actin-bundling protein 1 | |||||
Publication Statistics
PubMed Score 481.26
PubMed score by year
PubTator Score 394.54
PubTator score by year
Related Publications
Text Mined References (177)
GeneRif Annotations (141)
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0 of 0
PMID | Year | Title |
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