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Tdark
FRYL
Protein furry homolog-like

Protein Summary
Description
Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358350
  • ENSP00000351113
  • ENSG00000075539
  • ENST00000503238
  • ENSP00000426064

Symbol
  • AF4P12
  • KIAA0826
  • MOR2
  • AF4p12
  • KIAA0826
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.95
transcription factor binding site profile
0.82
transcription factor perturbation
0.8
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.999999825
p_ni:  1.75e-7
Score:  0.54
Data Source:  BioPlex,STRINGDB
PDZK1P1
Tdark
p_int:  0.999999693
p_ni:  3.07e-7
Data Source:  BioPlex
FRY
Tbio
Novelty:  0.14352873
p_int:  0.999998698
p_ni:  0.000001274
p_wrong:  2.9e-8
Score:  0.547
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999978577
p_ni:  0.000021422
Data Source:  BioPlex
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.996247407
p_ni:  0.003752593
Score:  0.439
Data Source:  BioPlex,STRINGDB
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.950331946
p_ni:  0.049668053
Score:  0.189
Data Source:  BioPlex,STRINGDB
RNF138
Tbio
Family:  TF
Novelty:  0.07543428
p_int:  0.906513116
p_ni:  0.093486884
Score:  0.175
Data Source:  BioPlex,STRINGDB
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.863329767
p_ni:  0.136670233
Score:  0.534
Data Source:  BioPlex,STRINGDB
FAM78B
Tdark
Novelty:  0.57441808
p_int:  0.819043855
p_ni:  0.180956145
Score:  0.209
Data Source:  BioPlex,STRINGDB
STK38L
Tchem
Family:  Kinase
Novelty:  0.05193219
Score:  0.761
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
2
2
74.6
hemoglobin measurement
2
2
2
71.6
platelet count
2
1
2
65.4
body height
1
1
1
64.9
hematocrit
2
2
2
55.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
74.6
hemoglobin measurement
2
71.6
platelet count
2
65.4
body height
1
64.9
hematocrit
2
55.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FRY like transcription coactivator
VGNC:2080
461340
Macaque
FRY like transcription coactivator
705707
Mouse
MGI:1919563
72313
Rat
RGD:1311309
364144
Dog
FRY like transcription coactivator
VGNC:40989
475139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FRY like transcription coactivator
Macaque
FRY like transcription coactivator
Mouse
Rat
Dog
FRY like transcription coactivator
Publication Statistics
PubMed Score 8.54
PubMed score by year
PubTator Score 10.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title