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Tdark
FRRS1
Ferric-chelate reductase 1

Protein Summary
Description
Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287474
  • ENSP00000287474
  • ENSG00000156869
  • ENST00000646001
  • ENSP00000496583

Symbol
  • SDFR2
  • SDR2
  • SDR2
  • SDFR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
transcription factor
0.63
cell line
0.61
cell type or tissue
0.59
transcription factor binding site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
CYB561
Tbio
Novelty:  0.15317924
Score:  0.931
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.738
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.738
Data Source:  STRINGDB
RPL27A
Tbio
Novelty:  0.03424762
Score:  0.738
Data Source:  STRINGDB
RPL8
Tbio
Novelty:  0.01064076
Score:  0.734
Data Source:  STRINGDB
RPS24
Tbio
Novelty:  0.01928704
Score:  0.734
Data Source:  STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
Score:  0.734
Data Source:  STRINGDB
RPS15
Tbio
Novelty:  0.00635155
Score:  0.734
Data Source:  STRINGDB
RPLP0
Tbio
Novelty:  0.00398127
Score:  0.734
Data Source:  STRINGDB
RPS4X
Tbio
Novelty:  0.01396038
Score:  0.734
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ferric chelate reductase 1
VGNC:6827
469391
Macaque
ferric chelate reductase 1
710829
Mouse
MGI:108076
20321
Rat
RGD:1306883
310810
Dog
ferric chelate reductase 1
VGNC:40985
490144
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ferric chelate reductase 1
Macaque
ferric chelate reductase 1
Mouse
Rat
Dog
ferric chelate reductase 1
Publication Statistics
PubMed Score 23.02
PubMed score by year
PubTator Score 3.50
PubTator score by year
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Related Publications
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PMID
Year
Title