Tbio FRMPD4 FERM and PDZ domain-containing protein 4

Protein Summary

Description

Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate. This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• Q14CM0
• A8K0X9
• O15032

Gene Name

• FRMPD4

Ensembl ID

• ENST00000380682
• ENSP00000370057
• ENSG00000169933

Symbol

• KIAA0316
• PDZD10
• PDZK10
• MRX104
• PDZD10
• PDZK10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.93
protein domain	0.92
microRNA	0.63
cell line	0.59
interacting protein	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.72   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 36   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.72   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0