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Tdark
FRMD8
FERM domain-containing protein 8

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317568
  • ENSP00000319726
  • ENSG00000126391
  • ENST00000355991
  • ENSP00000348270
  • ENST00000416776
  • ENSP00000392111

Symbol
  • iTAP
  • FKSG44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.82
kinase perturbation
0.71
cell type or tissue
0.7
transcription factor binding site profile
0.69
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.75   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.75   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
FRMD8P1
Tdark
p_int:  1
Data Source:  BioPlex
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.99902525
p_ni:  0.00097475
Score:  0.187
Data Source:  BioPlex,STRINGDB
FAM89B
Tbio
Novelty:  0.10306021
Score:  0.815
Data Source:  STRINGDB
FAM174A
Tdark
Novelty:  0.30693139
Score:  0.795
Data Source:  STRINGDB
SLC25A45
Tdark
Family:  Transporter
Novelty:  0.61869123
Score:  0.791
Data Source:  STRINGDB
EHBP1L1
Tdark
Novelty:  0.39557718
Score:  0.786
Data Source:  STRINGDB
SSSCA1
Tdark
Novelty:  0.53523038
Score:  0.782
Data Source:  STRINGDB
TIGD3
Tdark
Novelty:  1.23642174
Score:  0.743
Data Source:  STRINGDB
FNDC7
Tdark
Novelty:  6.38662445
Score:  0.73
Data Source:  STRINGDB
LTBP3
Tbio
Novelty:  0.0190763
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
2
2
3
91.9
glomerular filtration rate
2
2
3
88.3
BMI-adjusted hip circumference
4
11
12
85.2
uric acid measurement
2
2
2
74
serum alanine aminotransferase measurement
2
2
1
7.3
73.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
3
91.9
glomerular filtration rate
3
88.3
BMI-adjusted hip circumference
12
85.2
uric acid measurement
2
74
serum alanine aminotransferase measurement
1
7.3
73.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FERM domain containing 8
716379
Mouse
MGI:1914707
67457
Rat
RGD:1310323
309172
Dog
FERM domain containing 8
VGNC:51873
483739
Horse
FERM domain containing 8 [Source:HGNC Symbol;Acc:HGNC:25462]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FERM domain containing 8
Mouse
Rat
Dog
FERM domain containing 8
Horse
FERM domain containing 8 [Source:HGNC Symbol;Acc:HGNC:25462]
Publication Statistics
PubMed Score 2.75
PubMed score by year
PubTator Score 0.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title