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Tbio
FRMD6
FERM domain-containing protein 6

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344768
  • ENSP00000343899
  • ENSG00000139926
  • ENST00000356218
  • ENSP00000348550
  • ENST00000395718
  • ENSP00000379068
  • ENST00000553556
  • ENSP00000452529

Symbol
  • C14orf31
  • EX1
  • Willin
  • C14orf31
  • c14_5320
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.97
transcription factor perturbation
0.91
gene perturbation
0.77
transcription factor
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.24   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.24   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
RASSF8
Tbio
Novelty:  0.09245647
p_int:  1
Score:  0.704
Data Source:  BioPlex,STRINGDB
MAK16
Tdark
Novelty:  0.07717917
p_int:  0.999999793
p_ni:  2.07e-7
Score:  0.152
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.999993692
p_ni:  0.000006071
p_wrong:  2.37e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
TP53BP2
Tbio
Novelty:  0.01058379
p_int:  0.999902327
p_ni:  0.000097673
Score:  0.864
Data Source:  BioPlex,STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.999693424
p_ni:  0.000249711
p_wrong:  0.000056866
Score:  0.674
Data Source:  BioPlex,STRINGDB
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.881923474
p_ni:  0.118076425
p_wrong:  1.01e-7
Score:  0.222
Data Source:  BioPlex,STRINGDB
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.753738177
p_ni:  0.000275043
p_wrong:  0.24598678
Data Source:  BioPlex
WWC1
Tbio
Novelty:  0.00905646
Score:  0.957
Data Source:  STRINGDB
NF2
Tbio
Novelty:  0.00055092
Score:  0.95
Data Source:  STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
Score:  0.811
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
1
2
2
27.2
BMI-adjusted waist-hip ratio
1
2
2
24.2
BMI-adjusted waist circumference
1
1
1
9.5
waist circumference
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
27.2
BMI-adjusted waist-hip ratio
2
24.2
BMI-adjusted waist circumference
1
9.5
waist circumference
1
7.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 6
VGNC:3421
467455
Macaque
FERM domain containing 6
707266
Mouse
MGI:2442579
319710
Rat
RGD:727810
257646
Dog
FERM domain containing 6
VGNC:40983
490688
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 6
Macaque
FERM domain containing 6
Mouse
Rat
Dog
FERM domain containing 6
Publication Statistics
PubMed Score 266.24
PubMed score by year
PubTator Score 167.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title