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Tbio
FRMD5
FERM domain-containing protein 5

Protein Summary
Description
May be involved in regulation of cell migration (PubMed:22846708, PubMed:25448675). May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation (PubMed:25448675).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000417257
  • ENSP00000403067
  • ENSG00000171877
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.99
tissue sample
0.67
transcription factor binding site profile
0.64
histone modification site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.13   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.999994546
p_ni:  0.000005453
p_wrong:  1e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
PCDHAC2
Tdark
Novelty:  0.28397695
p_int:  0.999815311
p_ni:  0.000184329
p_wrong:  3.6e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.994873826
p_ni:  0.001474721
p_wrong:  0.003651453
Data Source:  BioPlex
PCDHA12
Tdark
Novelty:  0.71618264
p_int:  0.992989346
p_ni:  0.005580815
p_wrong:  0.001429839
Data Source:  BioPlex
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.991960489
p_ni:  0.000800216
p_wrong:  0.007239295
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.983629747
p_ni:  0.000326797
p_wrong:  0.016043456
Data Source:  BioPlex
ENPEP
Tchem
Family:  Enzyme
Novelty:  0.00112857
p_int:  0.981933089
p_ni:  0.008895821
p_wrong:  0.00917109
Score:  0.407
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.929064784
p_ni:  0.005347141
p_wrong:  0.065588074
Data Source:  BioPlex
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.923877274
p_ni:  0.023021771
p_wrong:  0.053100956
Data Source:  BioPlex
FBXO10
Tbio
Novelty:  0.18324932
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
7
4
11
5.1
94.1
high density lipoprotein cholesterol measurement
3
4
8
88.7
serum albumin measurement
2
2
2
88.4
lipoprotein-associated phospholipase A(2) measurement
1
3
0
7.3
68.8
IGF-1 measurement
1
1
1
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
5.1
94.1
high density lipoprotein cholesterol measurement
8
88.7
serum albumin measurement
2
88.4
lipoprotein-associated phospholipase A(2) measurement
0
7.3
68.8
IGF-1 measurement
1
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 5
VGNC:11893
453389
Macaque
FERM domain containing 5
711670
Mouse
MGI:2442557
228564
Rat
RGD:1561554
311362
Dog
FERM domain containing 5
VGNC:40982
478282
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 5
Macaque
FERM domain containing 5
Mouse
Rat
Dog
FERM domain containing 5
Publication Statistics
PubMed Score 6.13
PubMed score by year
PubTator Score 2.04
PubTator score by year
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Related Publications
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PMID
Year
Title