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Tbio
FRMD4A
FERM domain-containing protein 4A

Protein Summary
Description
Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRMD4B in epithelial polarization (By similarity). May regulate MAPT secretion by activating ARF6-signaling (PubMed:27044754). This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357447
  • ENSP00000350032
  • ENSG00000151474

Symbol
  • FRMD4
  • KIAA1294
  • FRMD4
  • CCAFCA
  • bA295P9.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.97
kinase perturbation
0.91
PubMedID
0.79
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.21   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.21   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.99998929
p_ni:  0.000007404
p_wrong:  0.000003306
Data Source:  BioPlex
CYTH4
Tbio
Novelty:  0.05783135
p_int:  0.99998881
p_ni:  0.000007263
p_wrong:  0.000003928
Data Source:  BioPlex
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.997090454
p_ni:  2.57e-7
p_wrong:  0.002909289
Score:  0.188
Data Source:  BioPlex,STRINGDB
PARD3B
Tbio
Novelty:  0.09155541
Score:  0.752
Data Source:  STRINGDB
DCAKD
Tdark
Family:  Enzyme
Novelty:  1.5418995
Score:  0.662
Data Source:  STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
Score:  0.638
Data Source:  STRINGDB
RITA1
Tbio
Novelty:  0.11311996
Score:  0.601
Data Source:  STRINGDB
MEGF6
Tdark
Novelty:  0.19604242
Score:  0.586
Data Source:  STRINGDB
C11orf52
Tdark
Novelty:  1.17961011
Score:  0.581
Data Source:  STRINGDB
TMEM150A
Tbio
Novelty:  0.12446897
Score:  0.577
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
95.5
daytime rest measurement
1
1
1
75.5
hemoglobin measurement
2
1
2
70.2
hematocrit
2
1
2
69.8
red blood cell density measurement
1
1
1
63.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
95.5
daytime rest measurement
1
75.5
hemoglobin measurement
2
70.2
hematocrit
2
69.8
red blood cell density measurement
1
63.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 4A
VGNC:12334
450316
Mouse
MGI:1919850
209630
Dog
FERM domain containing 4A
VGNC:40980
607414
Horse
FERM domain containing 4A
VGNC:18127
100056511
Cow
FERM domain containing 4A
VGNC:29114
510714
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 4A
Mouse
Dog
FERM domain containing 4A
Horse
FERM domain containing 4A
Cow
FERM domain containing 4A
Publication Statistics
PubMed Score 12.21
PubMed score by year
PubTator Score 14.48
PubTator score by year
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Related Publications
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PMID
Year
Title