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Tbio
FRMD3
FERM domain-containing protein 3

Protein Summary
Description
Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304195
  • ENSP00000303508
  • ENSG00000172159
  • ENST00000328788
  • ENSP00000328615
  • ENST00000376434
  • ENSP00000365617
  • ENST00000376438
  • ENSP00000365621
  • ENST00000621208
  • ENSP00000484839

Symbol
  • EPB41L4O
  • 4.1O
  • P410
  • EPB41LO
  • EPB41L4O
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.83
histone modification site profile
0.78
phenotype
0.65
PubMedID
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.999869053
p_ni:  0.000130947
Data Source:  BioPlex
LCLAT1
Tbio
Family:  Enzyme
Novelty:  0.03234576
p_int:  0.999694091
p_ni:  0.000305909
Score:  0.173
Data Source:  BioPlex,STRINGDB
KLHL15
Tbio
Novelty:  0.54712519
p_int:  0.971720995
p_ni:  0.028279005
Data Source:  BioPlex
REEP4
Tbio
Novelty:  0.37950931
p_int:  0.94947037
p_ni:  0.050528359
p_wrong:  0.000001271
Score:  0.158
Data Source:  BioPlex,STRINGDB
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.932572719
p_ni:  0.067427281
Data Source:  BioPlex
LARGE2
Tbio
Family:  Enzyme
Novelty:  0.11843777
p_int:  0.90097452
p_ni:  0.098471577
p_wrong:  0.000553903
Score:  0.173
Data Source:  BioPlex,STRINGDB
CKAP4
Tbio
Novelty:  0.02104039
p_int:  0.818397085
p_ni:  0.181602915
Data Source:  BioPlex
LMBR1
Tbio
Novelty:  0.00591824
p_int:  0.798348665
p_ni:  0.200123894
p_wrong:  0.001527442
Score:  0.208
Data Source:  BioPlex,STRINGDB
RASEF
Tbio
Novelty:  0.08877022
Score:  0.826
Data Source:  STRINGDB
NPAP1
Tbio
Novelty:  0.1488284
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
43.5
educational attainment
1
2
2
25.8
BMI-adjusted hip circumference
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
43.5
educational attainment
2
25.8
BMI-adjusted hip circumference
1
2.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 3
VGNC:4742
464549
Macaque
FERM domain containing 3
713394
Mouse
MGI:2442466
242506
Rat
RGD:1304802
298141
Dog
FERM domain containing 3
VGNC:40979
484151
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FERM domain containing 3
Macaque
FERM domain containing 3
Mouse
Rat
Dog
FERM domain containing 3
Publication Statistics
PubMed Score 34.54
PubMed score by year
PubTator Score 18.29
PubTator score by year
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Related Publications
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PMID
Year
Title