Tbio FRAT2 GSK-3-binding protein FRAT2

Protein Summary

Description

Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75474
• Q5JTI0
• Q8WUL9
• Q9BYG2

Gene Name

• FRAT2

Ensembl ID

• ENST00000371019
• ENSP00000360058
• ENSG00000181274

Symbol

• FRAT-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
transcription factor binding site profile	0.9
gene perturbation	0.88
disease perturbation	0.83
PubMedID	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.16   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.16   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0