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Tbio
FRAT1
Proto-oncogene FRAT1

Protein Summary
Description
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371021
  • ENSP00000360060
  • ENSG00000165879
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
PubMedID
0.7
gene perturbation
0.65
transcription factor
0.6
histone modification site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.07   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.07   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.859414764
p_ni:  1e-9
p_wrong:  0.140585235
Score:  0.895
Data Source:  BioPlex,STRINGDB
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
Score:  0.994
Data Source:  Reactome,STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.976
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.949
Data Source:  STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.935
Data Source:  STRINGDB
APC
Tchem
Novelty:  0.00168376
Score:  0.926
Data Source:  STRINGDB
CSNK1A1
Tchem
Family:  Kinase
Novelty:  0.00636472
Score:  0.919
Data Source:  STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
Score:  0.909
Data Source:  STRINGDB
PPP2R5C
Tbio
Family:  Enzyme
Novelty:  0.03336609
Score:  0.907
Data Source:  STRINGDB
AMER1
Tbio
Novelty:  0.00951499
Score:  0.903
Data Source:  STRINGDB
Pathways (26)
Beta-catenin phosphorylation cascade (R-HSA-196299)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin phosphorylation cascade
Reactome
Degradation of beta-catenin by the destruction complex
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Reactome
Signal Transduction
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Beta-catenin phosphorylation cascade
Degradation of beta-catenin by the destruction complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signal Transduction
Signaling by WNT
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
4
4
97.8
neutrophil count
4
4
5
97.8
myeloid white cell count
3
3
3
95.8
leukocyte count
2
3
3
95.2
monocyte percentage of leukocytes
2
2
2
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
97.8
neutrophil count
5
97.8
myeloid white cell count
3
95.8
leukocyte count
3
95.2
monocyte percentage of leukocytes
2
90.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FRAT1, WNT signaling pathway regulator
705609
Mouse
MGI:1351637
27412
Rat
RGD:1307664
308692
Cow
FRAT1, WNT signaling pathway regulator
505664
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FRAT1, WNT signaling pathway regulator
Mouse
Rat
Cow
FRAT1, WNT signaling pathway regulator
Publication Statistics
PubMed Score 31.07
PubMed score by year
PubTator Score 19.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title