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Tbio
FRA10AC1
Protein FRA10AC1

Protein Summary
Description
The protein encoded by this gene is a nuclear phosphoprotein of unknown function. This gene contains a tandem CGG repeat region within a CpG island that normally consists of 8-14 repeats but can expand to over 200 repeats. The repeat region is within the 5' UTR of some transcript variants, but is intronic to another variant. The expanded repeat allele is a fragile site and becomes hypermethylated, causing a reduction in gene expression. A disease phenotype has not been associated with expanded alleles. This gene is found within the rare FRA10A folate-sensitive fragile site. [provided by RefSeq, Dec 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.77
transcription factor perturbation
0.68
tissue sample
0.56
kinase perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.17   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ESS2
Tbio
Novelty:  0.00163665
p_int:  0.998623885
p_ni:  0.001374666
p_wrong:  0.000001448
Score:  0.828
Data Source:  BioPlex,STRINGDB
FUOM
Tbio
Family:  Enzyme
Novelty:  0.0562349
p_int:  0.93176965
p_ni:  0.067451344
p_wrong:  0.000779006
Score:  0.19
Data Source:  BioPlex,STRINGDB
FGF9
Tbio
Novelty:  0.003428
p_int:  0.930104688
p_ni:  0.069895138
p_wrong:  1.75e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
ALOX5AP
Tchem
Family:  Enzyme
Novelty:  0.00165143
p_int:  0.92896959
p_ni:  0.070874295
p_wrong:  0.000156115
Score:  0.517
Data Source:  BioPlex,STRINGDB
MTUS2
Tbio
Novelty:  0.13504593
p_int:  0.924956513
p_ni:  0.07504329
p_wrong:  1.97e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.918780843
p_ni:  0.008919724
p_wrong:  0.072299433
Data Source:  BioPlex
LENG1
Tdark
Novelty:  1.81219077
p_int:  0.858797911
p_ni:  0.14112967
p_wrong:  0.000072419
Score:  0.826
Data Source:  BioPlex,STRINGDB
WASF3
Tbio
Novelty:  0.0248378
p_int:  0.833013819
p_ni:  0.166955607
p_wrong:  0.000030575
Score:  0.169
Data Source:  BioPlex,STRINGDB
ZNF32
Tdark
Family:  TF
Novelty:  0.31051517
Score:  0.901
Data Source:  STRINGDB
PDE6C
Tclin
Family:  Enzyme
Novelty:  0.02239368
Score:  0.803
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
92.8
BMI-adjusted waist-hip ratio
4
5
8
87.9
vitamin A measurement
1
1
1
84.6
BMI-adjusted waist circumference
2
2
2
58.4
waist-hip ratio
2
1
2
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
92.8
BMI-adjusted waist-hip ratio
8
87.9
vitamin A measurement
1
84.6
BMI-adjusted waist circumference
2
58.4
waist-hip ratio
2
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FRA10A associated CGG repeat 1
VGNC:14559
450618
Macaque
fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
700389
Mouse
MGI:1917817
70567
Rat
RGD:1309482
365458
Dog
FRA10A associated CGG repeat 1
VGNC:52992
477776
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FRA10A associated CGG repeat 1
Macaque
fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
Mouse
Rat
Dog
FRA10A associated CGG repeat 1
Publication Statistics
PubMed Score 7.17
PubMed score by year
PubTator Score 1.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title