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Tchem
FPR2
N-formyl peptide receptor 2

Protein Summary
Description
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340023
  • ENSP00000340191
  • ENSG00000171049
  • ENST00000598776
  • ENSP00000468897
  • ENST00000598953
  • ENSP00000468876

Symbol
  • FPRH1
  • FPRL1
  • LXA4R
  • ALXR
  • HM63
  • FMLPX
  • FPR2A
  • FPRH1
  • FPRH2
  • FPRL1
  • LXA4R
  • FMLP-R-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.95
ligand (chemical)
0.94
gene perturbation
0.76
microRNA
0.76
phenotype
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.02   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 373   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.02   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 373   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 347
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (347)
LXA<sub>4</sub>
Rendered image for LXA<sub>4</sub>
resolvin D1
Rendered image for resolvin D1
pyrazolone, 1
Rendered image for pyrazolone, 1
aspirin-triggered resolvin D1
Rendered image for aspirin-triggered resolvin D1
RvD1-ME
Rendered image for RvD1-ME
CHEMBL4744094
Rendered image for CHEMBL4744094
CHEMBL4743917
Rendered image for CHEMBL4743917
CHEMBL4744835
Rendered image for CHEMBL4744835
CHEMBL4793557
Rendered image for CHEMBL4793557
Protein-Protein Interactions (579)
FUNDC2
Tbio
Novelty:  0.09695817
p_int:  0.99996438
p_ni:  0.000035608
p_wrong:  1.2e-8
Data Source:  BioPlex
REEP6
Tbio
Novelty:  0.10645981
p_int:  0.999936527
p_ni:  0.000063473
Data Source:  BioPlex
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.999578057
p_ni:  0.000421943
Data Source:  BioPlex
SLC38A9
Tbio
Family:  Transporter
Novelty:  0.0879703
p_int:  0.999464393
p_ni:  0.000514957
p_wrong:  0.000020651
Data Source:  BioPlex
FNDC3A
Tbio
Novelty:  0.04721453
p_int:  0.999365057
p_ni:  0.000634803
p_wrong:  1.39e-7
Data Source:  BioPlex
SLC30A5
Tbio
Family:  Transporter
Novelty:  0.02432633
p_int:  0.998917023
p_ni:  0.001082977
Data Source:  BioPlex
RRAGB
Tbio
Novelty:  0.02279777
p_int:  0.998789392
p_ni:  0.001207518
p_wrong:  0.00000309
Data Source:  BioPlex
ELOVL2
Tbio
Novelty:  0.00665823
p_int:  0.998617442
p_ni:  0.001323078
p_wrong:  0.00005948
Data Source:  BioPlex
ATP2B4
Tbio
Family:  Transporter
Novelty:  0.00560356
p_int:  0.998086371
p_ni:  0.001913629
Score:  0.165
Data Source:  BioPlex,STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
p_int:  0.996482621
p_ni:  0.003154789
p_wrong:  0.000362589
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Formyl peptide receptors bind formyl peptides and many other ligands
Reactome
G alpha (i) signalling events
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
Formyl peptide receptors bind formyl peptides and many other ligands
G alpha (i) signalling events
G alpha (q) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
5
7
93.8
blood protein measurement
2
2
2
75.1
eosinophil count
2
2
2
72.4
monocyte count
2
2
2
67.4
eosinophil percentage of leukocytes
1
1
1
60.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
7
93.8
blood protein measurement
2
75.1
eosinophil count
2
72.4
monocyte count
2
67.4
eosinophil percentage of leukocytes
1
60.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
formyl peptide receptor 2
100426968
Mouse
MGI:1194495
14294
Rat
RGD:1584013
690158
Dog
formyl peptide receptor 2
611696
Horse
N-formyl peptide receptor 2-like
100062735
Species
Name
OMA
EggNOG
Inparanoid
Macaque
formyl peptide receptor 2
Mouse
Rat
Dog
formyl peptide receptor 2
Horse
N-formyl peptide receptor 2-like
Publication Statistics
PubMed Score 561.02
PubMed score by year
PubTator Score 286.80
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title