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Tbio
FOXRED1
FAD-dependent oxidoreductase domain-containing protein 1

Protein Summary
Description
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554). This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263578
  • ENSP00000263578
  • ENSG00000110074
  • ENST00000532125
  • ENSP00000434178

Symbol
  • H17
  • FP634
  • MC1DN19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
cell type or tissue
0.77
kinase perturbation
0.76
transcription factor binding site profile
0.71
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.98   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.98   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
RTN4IP1
Tbio
Family:  Enzyme
Novelty:  0.01274213
p_int:  0.999997259
p_ni:  0.000002741
Score:  0.158
Data Source:  BioPlex,STRINGDB
SUGCT
Tbio
Family:  Enzyme
Novelty:  0.0075902
p_int:  0.999559835
p_ni:  0.000352958
p_wrong:  0.000087207
Score:  0.238
Data Source:  BioPlex,STRINGDB
COPRS
Tbio
Novelty:  0.03545787
p_int:  0.99936743
p_ni:  0.000632538
p_wrong:  3.2e-8
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.984271055
p_ni:  0.015728945
Data Source:  BioPlex
CLPX
Tbio
Family:  Enzyme
Novelty:  0.00254331
p_int:  0.963647743
p_ni:  0.036352257
Score:  0.371
Data Source:  BioPlex,STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
p_int:  0.953801899
p_ni:  0.046198101
Score:  0.23
Data Source:  BioPlex,STRINGDB
MTIF2
Tbio
Novelty:  0.06681774
p_int:  0.953241093
p_ni:  0.046758907
Score:  0.161
Data Source:  BioPlex,STRINGDB
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.926098698
p_ni:  0.055018318
p_wrong:  0.018882985
Score:  0.793
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.902720038
p_ni:  0.097279962
Data Source:  BioPlex
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
p_int:  0.901512982
p_ni:  0.098486763
p_wrong:  2.55e-7
Score:  0.307
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
WikiPathways
Mitochondrial complex I assembly model OXPHOS system
Name
Explore in Pharos
Explore in Source
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Mitochondrial complex I assembly model OXPHOS system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
10
12
19
98.5
apolipoprotein B measurement
2
6
6
98
total cholesterol measurement
6
8
15
96
calcium measurement
1
2
2
91.9
ST2 protein measurement
1
1
1
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
19
98.5
apolipoprotein B measurement
6
98
total cholesterol measurement
15
96
calcium measurement
2
91.9
ST2 protein measurement
1
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAD dependent oxidoreductase domain containing 1
VGNC:6557
451653
Macaque
FAD dependent oxidoreductase domain containing 1
714271
Mouse
MGI:2446262
235169
Dog
FAD dependent oxidoreductase domain containing 1
VGNC:40971
100856312
Horse
FAD dependent oxidoreductase domain containing 1
VGNC:18119
100072450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAD dependent oxidoreductase domain containing 1
Macaque
FAD dependent oxidoreductase domain containing 1
Mouse
Dog
FAD dependent oxidoreductase domain containing 1
Horse
FAD dependent oxidoreductase domain containing 1
Publication Statistics
PubMed Score 18.98
PubMed score by year
PubTator Score 7.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title