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Tbio
FOXR1
Forkhead box protein R1

Protein Summary
Description
This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317011
  • ENSP00000314806
  • ENSG00000176302
  • ENST00000531539
  • ENSP00000433394
  • ENST00000626640
  • ENSP00000487495
  • ENSG00000281277
  • ENST00000634955
  • ENSP00000489241

Symbol
  • FOXN5
  • FOXN5
  • DLNB13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.47
biological process
0.46
cellular component
0.42
chemical
0.41
tissue
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
MYC
Tchem
Family:  TF
Novelty:  0.00005734
p_int:  0.999999269
p_ni:  7.3e-7
p_wrong:  1e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
EPC1
Tbio
Novelty:  0.03216371
p_int:  0.999993513
p_ni:  0.000006487
Score:  0.822
Data Source:  BioPlex,STRINGDB
EPC2
Tbio
Novelty:  0.02760809
p_int:  0.999993165
p_ni:  0.000006835
Score:  0.822
Data Source:  BioPlex,STRINGDB
MBTD1
Tbio
Family:  Epigenetic
Novelty:  0.11651052
p_int:  0.99997325
p_ni:  0.000025294
p_wrong:  0.000001456
Score:  0.812
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999966566
p_ni:  0.000033372
p_wrong:  6.2e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
p_int:  0.999964764
p_ni:  0.000035236
Score:  0.741
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.999959398
p_ni:  0.000040602
Score:  0.842
Data Source:  BioPlex,STRINGDB
ING3
Tbio
Family:  Epigenetic
Novelty:  0.01696145
p_int:  0.999953644
p_ni:  0.000043639
p_wrong:  0.000002718
Score:  0.818
Data Source:  BioPlex,STRINGDB
EP400
Tbio
Novelty:  0.02013098
p_int:  0.999929757
p_ni:  0.000070243
Score:  0.829
Data Source:  BioPlex,STRINGDB
BRD8
Tbio
Family:  Epigenetic
Novelty:  0.09769287
p_int:  0.999762611
p_ni:  0.000237389
Score:  0.852
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
3
0
1.1
88.8
body mass index
3
3
3
79.5
high density lipoprotein cholesterol measurement
1
1
1
73.9
3
2
2
1.1
69.7
waist-hip ratio
1
1
1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
88.8
body mass index
3
79.5
high density lipoprotein cholesterol measurement
1
73.9
2
1.1
69.7
waist-hip ratio
1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2685961
382074
Rat
RGD:1309739
315601
Dog
forkhead box R1
VGNC:40969
489376
Horse
forkhead box R1
VGNC:18117
100147225
Cow
forkhead box R1
VGNC:29104
788135
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
forkhead box R1
Horse
forkhead box R1
Cow
forkhead box R1
Publication Statistics
PubMed Score 7.44
PubMed score by year
PubTator Score 4.53
PubTator score by year
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Related Publications
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PMID
Year
Title