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Tbio
FOXP4
Forkhead box protein P4

Protein Summary
Description
Transcriptional repressor that represses lung-specific expression. This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307972
  • ENSP00000309823
  • ENSG00000137166
  • ENST00000373057
  • ENSP00000362148
  • ENST00000373060
  • ENSP00000362151
  • ENST00000373063
  • ENSP00000362154

Symbol
  • FKHLA
  • hFKHLA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor binding site profile
0.85
microRNA
0.72
biological process
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.4   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.4   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
FOXP2
Tbio
Family:  TF
Novelty:  0.00190504
p_int:  0.999999975
p_ni:  5e-9
p_wrong:  2e-8
Score:  0.831
Data Source:  BioPlex,STRINGDB
FOXP3
Tbio
Family:  TF
Novelty:  0.00017205
p_int:  0.999999641
p_ni:  3.58e-7
p_wrong:  1e-9
Score:  0.885
Data Source:  BioPlex,STRINGDB
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.999997854
p_ni:  0.000002135
p_wrong:  1.1e-8
Data Source:  BioPlex
DHDDS
Tbio
Family:  Enzyme
Novelty:  0.02877368
p_int:  0.999899559
p_ni:  0.000100441
Score:  0.536
Data Source:  BioPlex,STRINGDB
ASB3
Tbio
Novelty:  0.15921018
p_int:  0.999862355
p_ni:  0.000137645
p_wrong:  1e-9
Score:  0.208
Data Source:  BioPlex,STRINGDB
HAND1
Tbio
Family:  TF
Novelty:  0.00556481
Score:  0.931
Data Source:  STRINGDB
HAND2
Tbio
Family:  TF
Novelty:  0.00478924
Score:  0.75
Data Source:  STRINGDB
XAGE2
Tbio
Novelty:  0.15338981
Score:  0.723
Data Source:  STRINGDB
MAB21L2
Tbio
Novelty:  0.05770595
Score:  0.659
Data Source:  STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.652
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
89
2
2
1
1.2
85.2
sex hormone-binding globulin measurement
7
1
6
9.1
84.6
1
2
0
1.1
75
2
2
0
1.1
65.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
89
1
1.2
85.2
sex hormone-binding globulin measurement
6
9.1
84.6
0
1.1
75
0
1.1
65.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box P4
VGNC:2837
107975135
Macaque
forkhead box P4
693943
Mouse
MGI:1921373
74123
Dog
forkhead box P4
VGNC:40968
481793
Horse
forkhead box P4
VGNC:18116
100054333
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box P4
Macaque
forkhead box P4
Mouse
Dog
forkhead box P4
Horse
forkhead box P4
Publication Statistics
PubMed Score 54.40
PubMed score by year
PubTator Score 17.02
PubTator score by year
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Related Publications
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PMID
Year
Title