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Tbio
FOXP3
Forkhead box protein P3

Protein Summary
Description
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acet ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376199
  • ENSP00000365372
  • ENSG00000049768
  • ENST00000376207
  • ENSP00000365380
  • ENST00000518685
  • ENSP00000428952
  • ENST00000557224
  • ENSP00000451208

Symbol
  • IPEX
  • JM2
  • AIID
  • IPEX
  • PIDX
  • XPID
  • DIETER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.95
protein domain
0.85
tissue sample
0.77
tissue
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6973.94   (req: < 5)
Gene RIFs: 845   (req: <= 3)
Antibodies: 1751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6973.94   (req: >= 5)
Gene RIFs: 845   (req: > 3)
Antibodies: 1751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0