Tbio FOXO4 Forkhead box protein O4

Protein Summary

Description

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Uniprot Accession IDs

• P98177
• B7WPJ7
• O43821
• Q13720
• Q3KPF1
• Q8TDK9

Gene Name

• FOXO4

Ensembl ID

• ENST00000341558
• ENSP00000342209
• ENSG00000184481
• ENST00000374259
• ENSP00000363377

Symbol

• AFX
• AFX1
• MLLT7
• AFX
• AFX1
• MLLT7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.9
hub protein	0.88
histone modification site profile	0.78
biological term	0.77
kinase	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.95   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 891   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.95   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 891   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0