Tbio FOXO3 Forkhead box protein O3

Protein Summary

Description

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43524
• B4DVZ6
• E1P5E6
• O15171
• Q5T2I7
• Q9BZ04

Gene Name

• FOXO3

Ensembl ID

• ENST00000343882
• ENSP00000339527
• ENSG00000118689
• ENST00000406360
• ENSP00000385824
• ENST00000540898
• ENSP00000446316

Symbol

• FKHRL1
• FOXO3A
• FOXO2
• AF6q21
• FKHRL1
• FOXO3A
• FKHRL1P2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
kinase	1
hub protein	0.99
biological process	0.98
transcription factor	0.97

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1761.14   (req: < 5)

Gene RIFs: 700   (req: <= 3)

Antibodies: 1051   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1761.14   (req: >= 5)

Gene RIFs: 700   (req: > 3)

Antibodies: 1051   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0