You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FOXN3
Forkhead box protein N3

Protein Summary
Description
Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints). This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261302
  • ENSP00000261302
  • ENSG00000053254
  • ENST00000345097
  • ENSP00000343288
  • ENST00000555353
  • ENSP00000452227
  • ENST00000557258
  • ENSP00000452005
  • ENST00000615335
  • ENSP00000479114

Symbol
  • C14orf116
  • CHES1
  • CHES1
  • PRO1635
  • C14orf116
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
transcription factor perturbation
0.94
kinase perturbation
0.91
transcription factor
0.76
phenotype
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.05   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.05   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
RFX2
Tbio
Family:  TF
Novelty:  0.04660141
p_int:  0.999999956
p_ni:  4.3e-8
p_wrong:  2e-9
Score:  0.365
Data Source:  BioPlex,STRINGDB
RFX3
Tbio
Family:  TF
Novelty:  0.04646733
p_int:  0.999999926
p_ni:  7.3e-8
p_wrong:  1e-9
Score:  0.287
Data Source:  BioPlex,STRINGDB
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
p_int:  0.999998823
p_ni:  0.000001176
p_wrong:  1e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
ZBTB34
Tdark
Family:  TF
Novelty:  0.5693361
p_int:  0.999994942
p_ni:  0.000002318
p_wrong:  0.00000274
Score:  0.378
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.991449094
p_ni:  0.008550906
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.976479593
p_ni:  0.023520407
Score:  0.191
Data Source:  BioPlex,STRINGDB
DDB2
Tbio
Novelty:  0.00648809
p_int:  0.949917584
p_ni:  0.050082409
p_wrong:  7e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
Score:  0.967
Data Source:  STRINGDB
LONP2
Tbio
Family:  Enzyme
Novelty:  0.04499043
Score:  0.806
Data Source:  STRINGDB
MEN1
Tchem
Novelty:  0.00059287
Score:  0.688
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (83)
Find Similar Targets
Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
WikiPathways
Endoderm Differentiation
Name
Explore in Pharos
Explore in Source
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Endoderm Differentiation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
3
3
3
91.2
sex hormone-binding globulin measurement
7
1
6
5.8
75.3
testosterone measurement
3
1
3
74.3
intelligence
2
2
2
5.7
72.9
hemoglobin A1 measurement
1
1
1
64.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
3
91.2
sex hormone-binding globulin measurement
6
5.8
75.3
testosterone measurement
3
74.3
intelligence
2
5.7
72.9
hemoglobin A1 measurement
1
64.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
forkhead box N3
694756
Mouse
MGI:1918625
71375
Rat
RGD:1305711
314374
Dog
forkhead box N3
VGNC:49737
610880
Horse
forkhead box N3
VGNC:18111
100052973
Species
Name
OMA
EggNOG
Inparanoid
Macaque
forkhead box N3
Mouse
Rat
Dog
forkhead box N3
Horse
forkhead box N3
Publication Statistics
PubMed Score 45.05
PubMed score by year
PubTator Score 18.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title