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Tbio
FOXL2
Forkhead box protein L2

Protein Summary
Description
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharop ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330315
  • ENSP00000333188
  • ENSG00000183770
  • ENST00000648323
  • ENSP00000497217

Symbol
  • BPES
  • PFRK
  • POF3
  • BPES1
  • PINTO
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
molecular function
0.76
transcription factor binding site profile
0.66
PubMedID
0.63
biological term
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.19   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 504.19   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.976
Data Source:  Reactome,STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.948
Data Source:  Reactome,STRINGDB
NR5A1
Tchem
Family:  NR
Novelty:  0.00126037
Score:  0.936
Data Source:  STRINGDB
AMH
Tbio
Novelty:  0.00022501
Score:  0.931
Data Source:  STRINGDB
PIAS1
Tbio
Family:  TF
Novelty:  0.00987743
Score:  0.923
Data Source:  STRINGDB
CYP19A1
Tclin
Family:  Enzyme
Novelty:  0.0003187
Score:  0.918
Data Source:  STRINGDB
DMRT1
Tbio
Family:  TF
Novelty:  0.00403133
Score:  0.888
Data Source:  STRINGDB
SOX9
Tbio
Family:  TF
Novelty:  0.00047439
Score:  0.888
Data Source:  STRINGDB
RSPO1
Tbio
Novelty:  0.00365075
Score:  0.87
Data Source:  STRINGDB
WNT4
Tbio
Novelty:  0.00276803
Score:  0.852
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of transcription factors
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of transcription factors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
2
2
84.2
1
1
1
32.8
1
1
1
27.3
1
1
0
1.9
12.8
platelet count
1
1
1
6.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
84.2
1
32.8
1
27.3
0
1.9
12.8
platelet count
1
6.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1349428
26927
Rat
RGD:1310041
367152
Cow
forkhead box L2
VGNC:29093
281770
Pig
-
Opossum
forkhead box L2
100017397
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
forkhead box L2
Pig
-
Opossum
forkhead box L2
Publication Statistics
PubMed Score 504.19
PubMed score by year
PubTator Score 432.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title