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Tbio
FOXK1
Forkhead box protein K1

Protein Summary
Description
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity). Important regulatory factor of the myogenic progenitor cell population (By similarity). Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells (By similarity). Represses myogenic differentiation by inhibiting MEFC acitivity (By similarity). Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328914
  • ENSP00000328720
  • ENSG00000164916

Symbol
  • MNF
  • FOXK1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.87
transcription factor binding site profile
0.8
protein domain
0.73
biological process
0.7
cell line
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.11   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.11   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
AHCYL1
Tchem
Family:  Enzyme
Novelty:  0.02176432
p_int:  0.999994889
p_ni:  0.000005111
Data Source:  BioPlex
BAP1
Tbio
Family:  Enzyme
Novelty:  0.00501435
p_int:  0.999988043
p_ni:  0.000011957
Score:  0.965
Data Source:  BioPlex,Reactome,STRINGDB
DVL3
Tbio
Novelty:  0.01606014
p_int:  0.999951436
p_ni:  0.000048564
Score:  0.207
Data Source:  BioPlex,STRINGDB
ZNF428
Tdark
Novelty:  3.23887218
p_int:  0.99994598
p_ni:  0.00005402
Data Source:  BioPlex
AHCYL2
Tbio
Family:  Enzyme
Novelty:  0.08695339
p_int:  0.999822222
p_ni:  0.000177778
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.999760986
p_ni:  0.000239014
Data Source:  BioPlex
TP63
Tbio
Family:  TF
Novelty:  0.00336108
p_int:  0.999692971
p_ni:  0.000307029
Score:  0.174
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999580723
p_ni:  0.000419276
Data Source:  BioPlex
DVL2
Tbio
Novelty:  0.00833084
p_int:  0.99932598
p_ni:  0.00067402
Score:  0.239
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999322084
p_ni:  0.000677916
Score:  0.312
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

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1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
2
34.6
mosquito bite reaction itch intensity measurement
1
1
1
24.5
apolipoprotein A 1 measurement
1
1
1
21.5
parental longevity
1
1
1
17.8
electrocardiography
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
34.6
mosquito bite reaction itch intensity measurement
1
24.5
apolipoprotein A 1 measurement
1
21.5
parental longevity
1
17.8
electrocardiography
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box K1
VGNC:14013
100610392
Macaque
forkhead box K1
106997337
Mouse
MGI:1347488
17425
Rat
RGD:1309643
304298
Dog
forkhead box K1
VGNC:40957
489885
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box K1
Macaque
forkhead box K1
Mouse
Rat
Dog
forkhead box K1
Publication Statistics
PubMed Score 92.11
PubMed score by year
PubTator Score 31.05
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title