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Tbio
FOXJ1
Forkhead box protein J1

Protein Summary
Description
Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung. This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322957
  • ENSP00000323880
  • ENSG00000129654

Symbol
  • FKHL13
  • HFH4
  • HFH4
  • HFH-4
  • FKHL13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
gene perturbation
0.86
phenotype
0.68
PubMedID
0.59
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.14   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.14   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
TBC1D32
Tbio
Novelty:  0.25744084
p_int:  0.999999984
p_ni:  1.4e-8
p_wrong:  2e-9
Score:  0.374
Data Source:  BioPlex,STRINGDB
RFX1
Tbio
Family:  TF
Novelty:  0.00225236
p_int:  0.99999995
p_ni:  5e-8
Score:  0.687
Data Source:  BioPlex,STRINGDB
RFX3
Tbio
Family:  TF
Novelty:  0.04646733
p_int:  0.999999949
p_ni:  9e-9
p_wrong:  4.2e-8
Score:  0.932
Data Source:  BioPlex,STRINGDB
CDK20
Tbio
Family:  Kinase
Novelty:  0.01176977
p_int:  0.999999825
p_ni:  1.46e-7
p_wrong:  2.9e-8
Score:  0.435
Data Source:  BioPlex,STRINGDB
RFX2
Tbio
Family:  TF
Novelty:  0.04660141
p_int:  0.999998464
p_ni:  1.5e-8
p_wrong:  0.000001521
Score:  0.929
Data Source:  BioPlex,STRINGDB
PEX14
Tbio
Novelty:  0.0210557
p_int:  0.991703632
p_ni:  0.008296368
Score:  0.175
Data Source:  BioPlex,STRINGDB
ASPM
Tbio
Novelty:  0.00599688
p_int:  0.963754178
p_ni:  0.036245822
Score:  0.179
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.854087736
p_ni:  0.145912264
Data Source:  BioPlex
MCIDAS
Tbio
Novelty:  0.01249062
Score:  0.819
Data Source:  STRINGDB
SPAG6
Tbio
Novelty:  0.01327217
Score:  0.781
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (36)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
3
3
82
waist-hip ratio
1
2
2
75.7
comparative body size at age 10, self-reported
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
82
waist-hip ratio
2
75.7
comparative body size at age 10, self-reported
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box J1
VGNC:9287
454899
Macaque
forkhead box J1
706275
Mouse
MGI:1347474
15223
Dog
forkhead box J1
VGNC:40954
475917
Horse
forkhead box J1
VGNC:18103
100147129
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box J1
Macaque
forkhead box J1
Mouse
Dog
forkhead box J1
Horse
forkhead box J1
Publication Statistics
PubMed Score 142.14
PubMed score by year
PubTator Score 55.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title