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Tbio
FOXI1
Forkhead box protein I1

Protein Summary
Description
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity). This gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene may play an important role in the development of the cochlea and vestibulum, as well as in embryogenesis. The encoded protein has been found to be required for the transcription of four subunits of a proton pump found in the inner ear, the kidney, and the epididymis. Mutations in this gene have been associated with deafness, autosomal recessive 4. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306268
  • ENSP00000304286
  • ENSG00000168269
  • ENST00000449804
  • ENSP00000415483

Symbol
  • FKHL10
  • FREAC6
  • HFH3
  • FKH10
  • HFH-3
  • FKHL10
  • FREAC6
  • FREAC-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
molecular function
0.79
cell type or tissue
0.57
biological process
0.56
small molecule perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.5   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 438   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.5   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 438   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
SLC26A4
Tbio
Family:  Transporter
Novelty:  0.00162006
Score:  0.857
Data Source:  STRINGDB
ATP6V1B1
Tchem
Family:  Enzyme
Novelty:  0.01122589
Score:  0.809
Data Source:  STRINGDB
PAX8
Tchem
Family:  TF
Novelty:  0.0014232
Score:  0.744
Data Source:  STRINGDB
SRSF11
Tbio
Novelty:  0.17035604
Score:  0.663
Data Source:  STRINGDB
CA2
Tclin
Family:  Enzyme
Novelty:  0.00040118
Score:  0.646
Data Source:  STRINGDB
FBXO6
Tbio
Novelty:  0.02173918
Score:  0.643
Data Source:  STRINGDB
EYA1
Tbio
Novelty:  0.00585286
Score:  0.622
Data Source:  STRINGDB
GJB2
Tbio
Novelty:  0.00056398
Score:  0.61
Data Source:  STRINGDB
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
Score:  0.588
Data Source:  STRINGDB
SIX1
Tbio
Family:  TF
Novelty:  0.00415613
Score:  0.579
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box I1
VGNC:4006
471732
Macaque
forkhead box I1
700122
Mouse
MGI:1096329
14233
Rat
RGD:1307421
287185
Dog
forkhead box I1
VGNC:40951
489127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box I1
Macaque
forkhead box I1
Mouse
Rat
Dog
forkhead box I1
Publication Statistics
PubMed Score 44.50
PubMed score by year
PubTator Score 19.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title