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Tbio
FOXF2
Forkhead box protein F2

Protein Summary
Description
Probable transcription activator for a number of lung-specific genes. FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259806
  • ENSP00000259806
  • ENSG00000137273
  • ENST00000645481
  • ENSP00000496415

Symbol
  • FKHL6
  • FREAC2
  • FKHL6
  • FREAC2
  • FREAC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.8
transcription factor perturbation
0.8
PubMedID
0.78
molecular function
0.67
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.52   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.52   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
PRG2
Tbio
Novelty:  0.00548995
p_int:  0.999640049
p_ni:  0.000318575
p_wrong:  0.000041375
Data Source:  BioPlex
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.999629476
p_ni:  0.000082536
p_wrong:  0.000287988
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.999268643
p_ni:  0.000593269
p_wrong:  0.000138088
Score:  0.17
Data Source:  BioPlex,STRINGDB
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.999009362
p_ni:  0.000874924
p_wrong:  0.000115714
Score:  0.153
Data Source:  BioPlex,STRINGDB
ADAM30
Tdark
Family:  Enzyme
Novelty:  0.25395428
p_int:  0.96358095
p_ni:  0.008003277
p_wrong:  0.028415773
Score:  0.169
Data Source:  BioPlex,STRINGDB
ANTXR1
Tbio
Novelty:  0.00508081
p_int:  0.962575157
p_ni:  0.005368799
p_wrong:  0.032056044
Score:  0.224
Data Source:  BioPlex,STRINGDB
CCNJL
Tdark
Novelty:  2.86306774
p_int:  0.959811882
p_ni:  0.034552903
p_wrong:  0.005635215
Score:  0.19
Data Source:  BioPlex,STRINGDB
CRYBA4
Tbio
Novelty:  0.03692663
p_int:  0.942621915
p_ni:  0.004818874
p_wrong:  0.052559211
Score:  0.173
Data Source:  BioPlex,STRINGDB
THBS2
Tbio
Novelty:  0.00310724
p_int:  0.927673764
p_ni:  0.010344012
p_wrong:  0.061982224
Score:  0.218
Data Source:  BioPlex,STRINGDB
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.89526148
p_ni:  0.000274166
p_wrong:  0.104464354
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
86.4
balding measurement
1
2
2
27.3
testosterone measurement
1
1
1
14.1
Drug-induced agranulocytosis
1
1
0
17.4
11.5
response to anti-thyroid drug
1
1
0
17.4
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
86.4
balding measurement
2
27.3
testosterone measurement
1
14.1
Drug-induced agranulocytosis
0
17.4
11.5
response to anti-thyroid drug
0
17.4
11.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box F2
VGNC:11081
750558
Mouse
MGI:1347479
14238
Dog
forkhead box F2
VGNC:40950
100684911
Opossum
forkhead box F2
100028855
Xenopus
forkhead box F2
XB-GENE-484646
100101712
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box F2
Mouse
Dog
forkhead box F2
Opossum
forkhead box F2
Xenopus
forkhead box F2
Publication Statistics
PubMed Score 63.52
PubMed score by year
PubTator Score 28.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title