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Tbio
FOXE3
Forkhead box protein E3

Protein Summary
Description
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149). This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335071
  • ENSP00000334472
  • ENSG00000186790

Symbol
  • FKHL12
  • FREAC8
  • AAT11
  • ASGD2
  • FKHL12
  • FREAC8
  • CTRCT34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.57
biological process
0.54
tissue
0.5
phenotype
0.49
cell type or tissue
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.97   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.97   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
GPR161
Tbio
Family:  GPCR
Novelty:  0.00235739
Score:  0.908
Data Source:  STRINGDB
PITX3
Tbio
Family:  TF
Novelty:  0.00579075
Score:  0.785
Data Source:  STRINGDB
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.752
Data Source:  STRINGDB
PITX2
Tbio
Family:  TF
Novelty:  0.00216568
Score:  0.663
Data Source:  STRINGDB
B3GLCT
Tbio
Family:  Enzyme
Novelty:  0.02398944
Score:  0.644
Data Source:  STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.643
Data Source:  STRINGDB
MAF
Tbio
Family:  TF
Novelty:  0.00040887
Score:  0.608
Data Source:  STRINGDB
SIX3
Tbio
Family:  TF
Novelty:  0.00599946
Score:  0.587
Data Source:  STRINGDB
MAB21L1
Tbio
Novelty:  0.07438538
Score:  0.57
Data Source:  STRINGDB
VSX2
Tbio
Family:  TF
Novelty:  0.0046733
Score:  0.566
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
3
3
91.7
urinary albumin to creatinine ratio
4
3
5
90.4
corneal topography
2
2
2
56.2
BMI-adjusted hip circumference
1
2
2
53.2
hematocrit
1
2
2
34.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
3
91.7
urinary albumin to creatinine ratio
5
90.4
corneal topography
2
56.2
BMI-adjusted hip circumference
2
53.2
hematocrit
2
34.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1353569
30923
Rat
RGD:621727
171302
Dog
forkhead box E3
VGNC:54558
610277
Pig
forkhead box E3
100522259
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
forkhead box E3
Pig
forkhead box E3
Publication Statistics
PubMed Score 43.97
PubMed score by year
PubTator Score 29.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title