Tbio FOXE1 Forkhead box protein E1

Protein Summary

Description

Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression. This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]

Uniprot Accession IDs

• O00358
• O75765
• Q5T109
• Q99526

Gene Name

• FOXE1

Ensembl ID

• ENST00000375123
• ENSP00000364265
• ENSG00000178919

Symbol

• FKHL15
• FOXE2
• TITF2
• TTF2
• TTF2
• FOXE2
• HFKH4
• HFKL5
• NMTC4
• TITF2
• TTF-2
• FKHL15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.8
biological term	0.63
cell type or tissue	0.6
PubMedID	0.58
transcription factor binding site profile	0.52

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Forkhead Box Protein E1

Protein / Nucleic Acid Binding / Dna Binding Protein / Forkhead Box Protein E1

Protein / ... / Winged Helix/forkhead Transcription Factor / Forkhead Box Protein E1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Winged Helix/forkhead Transcription Factor / Forkhead Box Protein E1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.56   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 160.56   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0