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Tbio
FOXD3
Forkhead box protein D3

Protein Summary
Description
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371116
  • ENSP00000360157
  • ENSG00000187140

Symbol
  • HFH2
  • AIS1
  • HFH2
  • VAMAS2
  • Genesis
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
PubMedID
0.71
molecular function
0.7
transcription factor binding site profile
0.67
gene perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.79   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.79   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.984
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.979
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.973
Data Source:  STRINGDB
SOX10
Tbio
Family:  TF
Novelty:  0.00130552
Score:  0.931
Data Source:  STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.871
Data Source:  STRINGDB
MSX1
Tbio
Family:  TF
Novelty:  0.00176212
Score:  0.859
Data Source:  STRINGDB
PAX3
Tbio
Family:  TF
Novelty:  0.00140464
Score:  0.835
Data Source:  STRINGDB
SNAI2
Tbio
Family:  TF
Novelty:  0.00096495
Score:  0.819
Data Source:  STRINGDB
MITF
Tchem
Family:  TF
Novelty:  0.00094044
Score:  0.785
Data Source:  STRINGDB
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
Score:  0.762
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box D3
VGNC:548
456905
Macaque
forkhead box D3
696085
Mouse
MGI:1347473
15221
Dog
forkhead box D3
VGNC:53383
489558
Cow
forkhead box D3
VGNC:29082
532383
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box D3
Macaque
forkhead box D3
Mouse
Dog
forkhead box D3
Cow
forkhead box D3
Publication Statistics
PubMed Score 191.79
PubMed score by year
PubTator Score 71.22
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title