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Tbio
FOXA2
Hepatocyte nuclear factor 3-beta

Protein Summary
Description
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes im ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377115
  • ENSP00000366319
  • ENSG00000125798
  • ENST00000419308
  • ENSP00000400341

Symbol
  • HNF3B
  • TCF3B
  • HNF3B
  • TCF3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.92
molecular function
0.84
transcription factor binding site profile
0.75
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.7   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 808   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 419.7   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 808   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (236)
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.973
Data Source:  STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.969
Data Source:  STRINGDB
ONECUT1
Tbio
Family:  TF
Novelty:  0.0086548
Score:  0.915
Data Source:  STRINGDB
NKX2-2
Tbio
Family:  TF
Novelty:  0.00608835
Score:  0.911
Data Source:  STRINGDB
SOX17
Tbio
Family:  TF
Novelty:  0.00328146
Score:  0.903
Data Source:  STRINGDB
RPS6KB1
Tchem
Family:  Kinase
Novelty:  0.00044681
Score:  0.89
Data Source:  STRINGDB
RPS6KB2
Tchem
Family:  Kinase
Novelty:  0.02143353
Score:  0.876
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.873
Data Source:  STRINGDB
HNF4A
Tchem
Family:  NR
Novelty:  0.00041409
Score:  0.866
Data Source:  STRINGDB
OTX2
Tbio
Family:  TF
Novelty:  0.0024536
Score:  0.864
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
5
5
5
92.4
fasting blood glucose measurement
7
4
7
72.1
birth weight
1
1
1
36.5
body mass index
1
1
1
14.1
sex hormone-binding globulin measurement
2
1
2
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
5
92.4
fasting blood glucose measurement
7
72.1
birth weight
1
36.5
body mass index
1
14.1
sex hormone-binding globulin measurement
2
6.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
forkhead box A2
701771
Mouse
MGI:1347476
15376
Rat
RGD:2808
25099
Dog
forkhead box A2
VGNC:40944
485742
Horse
forkhead box A2
VGNC:51541
100147413
Species
Name
OMA
EggNOG
Inparanoid
Macaque
forkhead box A2
Mouse
Rat
Dog
forkhead box A2
Horse
forkhead box A2
Publication Statistics
PubMed Score 419.70
PubMed score by year
PubTator Score 263.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title