You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FOSL2
Fos-related antigen 2

Protein Summary
Description
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264716
  • ENSP00000264716
  • ENSG00000075426
  • ENST00000379619
  • ENSP00000368939

Symbol
  • FRA2
  • FRA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
kinase perturbation
0.99
transcription factor binding site profile
0.97
PubMedID
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.51   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 519   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.51   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 519   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  1
Score:  0.997
Data Source:  BioPlex,STRINGDB
JUND
Tbio
Family:  TF
Novelty:  0.00277701
p_int:  0.99999998
p_ni:  2e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.999999977
p_ni:  2.3e-8
Score:  0.79
Data Source:  BioPlex,STRINGDB
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  0.999999945
p_ni:  5.5e-8
Score:  0.611
Data Source:  BioPlex,STRINGDB
CREB5
Tbio
Family:  TF
Novelty:  0.03857106
p_int:  0.999999838
p_ni:  1.61e-7
Score:  0.748
Data Source:  BioPlex,STRINGDB
BACH2
Tbio
Family:  TF
Novelty:  0.00932069
p_int:  0.999998013
p_ni:  0.000001987
Score:  0.414
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
p_int:  0.999995346
p_ni:  0.000004654
Score:  0.996
Data Source:  BioPlex,STRINGDB
NBEA
Tbio
Novelty:  0.02583687
p_int:  0.999988165
p_ni:  0.000011835
Score:  0.187
Data Source:  BioPlex,STRINGDB
IRF2BPL
Tdark
Novelty:  0.05458595
p_int:  0.999975566
p_ni:  0.000024434
Score:  0.678
Data Source:  BioPlex,STRINGDB
IRF2BP1
Tdark
Novelty:  0.29719488
p_int:  0.999916957
p_ni:  0.000083043
Score:  0.672
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
92.9
hair color
1
3
0
1.1
91
eosinophil percentage of leukocytes
2
2
2
87.6
triglyceride measurement
3
3
3
81.3
2
2
0
1
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
92.9
hair color
0
1.1
91
eosinophil percentage of leukocytes
2
87.6
triglyceride measurement
3
81.3
0
1
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FOS like 2, AP-1 transcription factor subunit
703068
Mouse
MGI:102858
14284
Rat
RGD:2628
25446
Dog
FOS like 2, AP-1 transcription factor subunit
VGNC:40943
608412
Horse
FOS like 2, AP-1 transcription factor subunit
VGNC:18098
100071081
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FOS like 2, AP-1 transcription factor subunit
Mouse
Rat
Dog
FOS like 2, AP-1 transcription factor subunit
Horse
FOS like 2, AP-1 transcription factor subunit
Publication Statistics
PubMed Score 241.51
PubMed score by year
PubTator Score 85.07
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title